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Citation: Intensive Care Medicine Experimental 2023 11:86
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Circulating endothelial extracellular vesicle signatures correspond with ICU requirement: an exploratory study in COVID-19 patients
Extracellular vesicles (EVs) represent nanometer-sized, subcellular spheres, that are released from almost any cell type and carry a wide variety of biologically relevant cargo. In severe cases of coronavirus ...
Citation: Intensive Care Medicine Experimental 2023 11:85 -
Impact of critical illness on cholesterol and fatty acids: insights into pathophysiology and therapeutic targets
Critical illness is characterized by a hypercatabolic response encompassing endocrine and metabolic alterations. Not only the uptake, synthesis and metabolism of glucose and amino acids is majorly affected, bu...
Citation: Intensive Care Medicine Experimental 2023 11:84 -
Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach
Citation: Intensive Care Medicine Experimental 2023 11:83 -
Understanding the mechanisms of ventilator-induced lung injury using animal models
Mechanical ventilation is a life-saving therapy in several clinical situations, promoting gas exchange and providing rest to the respiratory muscles. However, mechanical ventilation may cause hemodynamic insta...
Citation: Intensive Care Medicine Experimental 2023 11:82 -
Ultra-low tidal volume ventilation during cardiopulmonary resuscitation shows no mitigating effect on pulmonary end-organ damage compared to standard ventilation: insights from a porcine model
This study aimed to determine whether ultra-low tidal volume ventilation (ULTVV) applied during cardiopulmonary resuscitation (CPR) compared with standard ventilation (intermittent positive pressure ventilatio...
Citation: Intensive Care Medicine Experimental 2023 11:81 -
Agreement of pCO2 in venous to arterial blood gas conversion models in undifferentiated emergency patients
Venous blood gas sampling has replaced arterial sampling in many critically ill patients, though interpretation of venous pCO2 still remains a challenge. Lemoël et al., Farkas and Zeserson et al. have proposed mo...
Citation: Intensive Care Medicine Experimental 2023 11:80 -
Body position to optimize mechanics in ARDS: to which degree does the angle matter?
Citation: Intensive Care Medicine Experimental 2023 11:79 -
Protective effect of canagliflozin on post-resuscitation myocardial function in a rat model of cardiac arrest
Currently, most patients with cardiac arrest (CA) show reversible myocardial dysfunction, hemodynamic instability, systemic inflammation and other pathophysiological state in early stage of resuscitation, some...
Citation: Intensive Care Medicine Experimental 2023 11:78 -
Current knowledge gaps in extracorporeal respiratory support
Extracorporeal life support (ECLS) for acute respiratory failure encompasses veno-venous extracorporeal membrane oxygenation (V-V ECMO) and extracorporeal carbon dioxide removal (ECCO2R). V-V ECMO is primarily us...
Citation: Intensive Care Medicine Experimental 2023 11:77 -
Hemodynamic effects of supplemental oxygen versus air in simulated blood loss in healthy volunteers: a randomized, controlled, double-blind, crossover trial
Trauma patients frequently receive supplemental oxygen, but its hemodynamic effects in blood loss are poorly understood. We studied the effects of oxygen on the hemodynamic response and tolerance to simulated ...
Citation: Intensive Care Medicine Experimental 2023 11:76 -
Continuous chest compressions are associated with higher peak inspiratory pressures when compared to 30:2 in an experimental cardiac arrest model
Ventilation during cardiopulmonary resuscitation (CPR) has long been a part of the standard treatment during cardiac arrests. Ventilation is usually given either during continuous chest compressions (CCC) or d...
Citation: Intensive Care Medicine Experimental 2023 11:75 -
Extracorporeal cardiopulmonary resuscitation in 2023
Citation: Intensive Care Medicine Experimental 2023 11:74 -
Diaphragm excursions as proxy for tidal volume during spontaneous breathing in invasively ventilated ICU patients
There is a need to monitor tidal volume in critically ill patients with acute respiratory failure, given its relation with adverse clinical outcome. However, quantification of tidal volume in non-intubated pat...
Citation: Intensive Care Medicine Experimental 2023 11:73 -
ESICM LIVES 2023
Citation: Intensive Care Medicine Experimental 2023 11(Suppl 1):72 -
Neurovirulent cytokines increase neuronal excitability in a model of coronavirus-induced neuroinflammation
Neurological manifestations of severe coronavirus infections, including SARS-CoV-2, are wide-ranging and may persist following virus clearance. Detailed understanding of the underlying changes in brain functio...
Citation: Intensive Care Medicine Experimental 2023 11:71 -
Comparison of whole blood cytokine immunoassays for rapid, functional immune phenotyping in critically ill patients with sepsis
Sepsis is characterized by highly heterogeneous immune responses associated with a spectrum of disease severity. Methods that rapidly and sensitively profile these immune responses can potentially personalize ...
Citation: Intensive Care Medicine Experimental 2023 11:70 -
Assessing neutrophil-derived ROS production at the bedside: a potential prognostic tool in severe COVID-19 cases
A prompt and effective immune response is required for clearance of pathogens but exaggerated states of inflammation can cause extensive collateral damage to the host. We have previously used a rapid near-pati...
Citation: Intensive Care Medicine Experimental 2023 11:69 -
Introductory editorial for the thematic collection “blood purification in sepsis: from bench to bedside” in intensive care medicine experimental
Citation: Intensive Care Medicine Experimental 2023 11:68 -
Reappraisal of intra-abdominal candidiasis: insights from peritoneal fluid analysis
The understanding of high mortality associated with intra-abdominal candidiasis (IAC) remains limited. While Candida is considered a harmless colonizer in the digestive tract, its role as a true pathogen in IAC i...
Citation: Intensive Care Medicine Experimental 2023 11:67 -
Neurofilament light chain on intensive care admission is an independent predictor of mortality in COVID-19: a prospective multicenter study
Neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total-tau protein (tau) are novel blood biomarkers of neurological injury, and may be used to predict outcomes in critical COVID-19.
Citation: Intensive Care Medicine Experimental 2023 11:66 -
Effects of changes in trunk inclination on ventilatory efficiency in ARDS patients: quasi-experimental study
Trunk inclination from semirecumbent head-upright to supine-flat positioning reduces driving pressure and increases respiratory system compliance in patients with acute respiratory distress syndrome (ARDS). Th...
Citation: Intensive Care Medicine Experimental 2023 11:65 -
Tissue oxygenation: how to measure, how much to target
Citation: Intensive Care Medicine Experimental 2023 11:64 -
Fluid restrictive resuscitation with high molecular weight hyaluronan infusion in early peritonitis sepsis
Sepsis is a condition with high morbidity and mortality. Prompt recognition and initiation of treatment is essential. Despite forming an integral part of sepsis management, fluid resuscitation may also lead to...
Citation: Intensive Care Medicine Experimental 2023 11:63 -
The effects of resuscitation with different plasma products on endothelial permeability and organ injury in a rat pneumosepsis model
Endothelial injury and permeability are a hallmark of sepsis. Initial resuscitation of septic patients with crystalloids is associated with aggravation of endothelial permeability, which may be related either ...
Citation: Intensive Care Medicine Experimental 2023 11:62 -
Perioperative advanced haemodynamic monitoring of patients undergoing multivisceral debulking surgery: an observational pilot study
Patients undergoing high-risk surgery show haemodynamic instability and an increased risk of morbidity. However, most of the available data concentrate on the intraoperative period. This study aims to characte...
Citation: Intensive Care Medicine Experimental 2023 11:61 -
Intra-tidal PaO2 oscillations associated with mechanical ventilation: a pilot study to identify discrete morphologies in a porcine model
Within-breath oscillations in arterial oxygen tension (PaO2) can be detected using fast responding intra-arterial oxygen sensors in animal models. These PaO2 signals, which rise in inspiration and fall in expirat...
Citation: Intensive Care Medicine Experimental 2023 11:60 -
Role of dexmedetomidine in modifying immune paralysis in patients with septic shock: randomized controlled trial
Immune paralysis can be defined as a hypoinflammatory state associated with the incapacity of the immune system to release proinflammatory mediators despite the clearance of pathogens by antimicrobials. Persis...
Citation: Intensive Care Medicine Experimental 2023 11:59 -
Timing and threshold of high sensitive troponin T measurement for the prediction of mortality after cardiac surgery: a retrospective cohort analysis
High sensitive cardiac troponin T (hsTnT) is a widely used biomarker of myocardial injury. Along with other high sensitive troponins, HsTnT can predict mortality in both cardiac and non-cardiac surgery. The ai...
Citation: Intensive Care Medicine Experimental 2023 11:58 -
Statistical properties of cerebral near infrared and intracranial pressure-based cerebrovascular reactivity metrics in moderate and severe neural injury: a machine learning and time-series analysis
Cerebrovascular reactivity has been identified as a key contributor to secondary injury following traumatic brain injury (TBI). Prevalent intracranial pressure (ICP) based indices of cerebrovascular reactivity...
Citation: Intensive Care Medicine Experimental 2023 11:57 -
Low‑to‑moderate hyperoxia in animal models: is there evidence for harm?
Citation: Intensive Care Medicine Experimental 2023 11:55 -
MesenchymAl stromal cells for Traumatic bRain Injury (MATRIx): a study protocol for a multicenter, double-blind, randomised, placebo-controlled phase II trial
Traumatic brain injury (TBI) is a significant cause of death and disability, with no effective neuroprotective drugs currently available for its treatment. Mesenchymal stromal cell (MSC)-based therapy shows pr...
Citation: Intensive Care Medicine Experimental 2023 11:56 -
Effect of norepinephrine on the vascular waterfall and tissue perfusion in vasoplegic hypotensive patients: a prospective, observational, applied physiology study in cardiac surgery
Norepinephrine is a commonly used drug for treating vasoplegic acute circulatory failure in ICU. The prediction of norepinephrine macro- and micro-circulatory response is complicated by its uneven receptors’ d...
Citation: Intensive Care Medicine Experimental 2023 11:52 -
Distinct host-response signatures in circulatory shock: a narrative review
Circulatory shock is defined syndromically as hypotension associated with tissue hypoperfusion and often subcategorized according to hemodynamic profile (e.g., distributive, cardiogenic, hypovolemic) and etiol...
Citation: Intensive Care Medicine Experimental 2023 11:50 -
Soluble TREM-1 plasma concentration predicts poor outcome in COVID-19 patients
The immuno-receptor Triggering Expressed on Myeloid cells-1 (TREM-1) is activated during bacterial infectious diseases, where it amplifies the inflammatory response. Small studies suggest that TREM-1 could be ...
Citation: Intensive Care Medicine Experimental 2023 11:51 -
Perioperative lung function following flow controlled ventilation for robot-assisted prostatectomies in steep trendelenburg position: an observational study
Steep Trendelenburg position combined with capnoperitoneum can lead to pulmonary complications and prolonged affection of postoperative lung function. Changes in pulmonary function occur independent of differe...
Citation: Intensive Care Medicine Experimental 2023 11:49 -
Clinical phenotypes and outcomes associated with SARS-CoV-2 Omicron variants BA.2, BA.5 and BQ.1.1 in critically ill patients with COVID-19: a prospective, multicenter cohort study
Despite current broad natural and vaccine-induced protection, a substantial number of patients infected with emerging SARS-CoV-2 variants (e.g., BF.7 and BQ.1.1) still experience severe COVID-19. Real-life stu...
Citation: Intensive Care Medicine Experimental 2023 11:48 -
The impact of sedative and vasopressor agents on cerebrovascular reactivity in severe traumatic brain injury
The aim of this study is to evaluate the impact of commonly administered sedatives (Propofol, Alfentanil, Fentanyl, and Midazolam) and vasopressor (Dobutamine, Ephedrine, Noradrenaline and Vasopressin) agents ...
Citation: Intensive Care Medicine Experimental 2023 11:54 -
Multiorgan recovery in a cadaver body using mild hypothermic ECMO treatment in a murine model
Transplant candidates on the waiting list are increasingly challenged by the lack of organs. Most of the organs can only be kept viable within very limited timeframes (e.g., mere 4–6 h for heart and lungs expo...
Citation: Intensive Care Medicine Experimental 2023 11:46 -
Splanchnic sympathetic nerve denervation improves bacterial clearance and clinical recovery in established ovine Gram-negative bacteremia
The autonomic nervous system can modulate the innate immune responses to bacterial infections via the splanchnic sympathetic nerves. Here, we aimed to determine the effects of bilateral splanchnic sympathetic ...
Citation: Intensive Care Medicine Experimental 2023 11:53 -
Weaning assessment of veno-arteriovenous (V-AV) extracorporeal membrane oxygenation (ECMO)
Currently, there is a lack of methods for simultaneous assessment of readiness for decannulation of the veno-venous (V-V) and veno-arterial (V-A) components during veno-arteriovenous (V-AV) extracorporal membr...
Citation: Intensive Care Medicine Experimental 2023 11:47 -
Fluid management strategies and their interaction with mechanical ventilation: from experimental studies to clinical practice
Patients on mechanical ventilation may receive intravenous fluids via restrictive or liberal fluid management. A clear and objective differentiation between restrictive and liberal fluid management strategies ...
Citation: Intensive Care Medicine Experimental 2023 11:44 -
Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions
Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Precli...
Citation: Intensive Care Medicine Experimental 2023 11:45 -
Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest
Definition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia–ischaemia and reperfusion. It may further explore interventi...
Citation: Intensive Care Medicine Experimental 2023 11:43 -
A closed-loop ventilation mode that targets the lowest work and force of breathing reduces the transpulmonary driving pressure in patients with moderate-to-severe ARDS
The driving pressure (ΔP) has an independent association with outcome in patients with acute respiratory distress syndrome (ARDS). INTELLiVENT-Adaptive Support Ventilation (ASV) is a closed-loop mode of ventilati...
Citation: Intensive Care Medicine Experimental 2023 11:42 -
Inferior vena cava distensibility from subcostal and trans-hepatic imaging using both M-mode or artificial intelligence: a prospective study on mechanically ventilated patients
Variation of inferior vena cava (IVC) is used to predict fluid-responsiveness, but the IVC visualization with standard sagittal approach (SC, subcostal) cannot be always achieved. In such cases, coronal trans-...
Citation: Intensive Care Medicine Experimental 2023 11:40 -
The metabolic cost of inspiratory muscle training in mechanically ventilated patients in critical care
Diaphragmatic dysfunction is well documented in patients receiving mechanical ventilation. Inspiratory muscle training (IMT) has been used to facilitate weaning by strengthening the inspiratory muscles, yet th...
Citation: Intensive Care Medicine Experimental 2023 11:41 -
Quadriceps handheld dynamometry during the post-ICU trajectory: using strictly the same body position is mandatory for repeated measures
The level of quadriceps strength (QS) generated in the supine or seated position is not similar. For QS follow-up from intensive care unit (ICU) stay to recovery, getting comparable measures is essential. This...
Citation: Intensive Care Medicine Experimental 2023 11:39 -
Efficacy of endotracheal tube clamping to prevent positive airways pressure loss and pressure behavior after reconnection: a bench study
Endotracheal tube (ETT) clamping before disconnecting the patient from the mechanical ventilator is routinely performed in patients with acute respiratory distress syndrome (ARDS) to minimize alveolar de-recru...
Citation: Intensive Care Medicine Experimental 2023 11:36 -
Colonic oxygen microbubbles augment systemic oxygenation and CO2 removal in a porcine smoke inhalation model of severe hypoxia
Inhalation injury can lead to pulmonary complications resulting in the development of respiratory distress and severe hypoxia. Respiratory distress is one of the major causes of death in critically ill patient...
Citation: Intensive Care Medicine Experimental 2023 11:35
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- ISSN: 2197-425X (electronic)