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Intensive Care Medicine Experimental
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  1. Variation of inferior vena cava (IVC) is used to predict fluid-responsiveness, but the IVC visualization with standard sagittal approach (SC, subcostal) cannot be always achieved. In such cases, coronal trans-...

    Authors: Filippo Sanfilippo, Luigi La Via, Veronica Dezio, Paolo Amelio, Giulio Genoese, Federico Franchi, Antonio Messina, Chiara Robba and Alberto Noto
    Citation: Intensive Care Medicine Experimental 2023 11:40
    Content type: Research Articles Published on:

  2. Diaphragmatic dysfunction is well documented in patients receiving mechanical ventilation. Inspiratory muscle training (IMT) has been used to facilitate weaning by strengthening the inspiratory muscles, yet th...

    Authors: Timothy O. Jenkins, Vicky MacBean, Mathias Krogh Poulsen, Dan Stieper Karbing, Stephen Edward Rees, Brijesh V. Patel and Michael I. Polkey
    Citation: Intensive Care Medicine Experimental 2023 11:41
    Content type: Research Articles Published on:

  3. The level of quadriceps strength (QS) generated in the supine or seated position is not similar. For QS follow-up from intensive care unit (ICU) stay to recovery, getting comparable measures is essential. This...

    Authors: Anne-Françoise Rousseau, Nadia Dardenne, Isabelle Kellens, Stephen Bornheim, Benoit Misset and Jean-Louis Croisier
    Citation: Intensive Care Medicine Experimental 2023 11:39
    Content type: Research Articles Published on:

  4. Endotracheal tube (ETT) clamping before disconnecting the patient from the mechanical ventilator is routinely performed in patients with acute respiratory distress syndrome (ARDS) to minimize alveolar de-recru...

    Authors: Enrico Bulleri, Cristian Fusi, Stefano Bambi, Luigi Pisani, Alice Galesi, Enrico Rizzello, Alberto Lucchini, Paolo Merlani and Alberto Pagnamenta
    Citation: Intensive Care Medicine Experimental 2023 11:36
    Content type: Research Articles Published on:

  5. Inhalation injury can lead to pulmonary complications resulting in the development of respiratory distress and severe hypoxia. Respiratory distress is one of the major causes of death in critically ill patient...

    Authors: Paul A. Mountford, Premila D. Leiphrakpam, Hannah R. Weber, Andrea McCain, Robert M. Scribner, Robert T. Scribner, Ernesto M. Duarte, Jie Chen, Dragana Noe, Mark A. Borden and Keely L. Buesing
    Citation: Intensive Care Medicine Experimental 2023 11:35
    Content type: Research Articles Published on:

  7. Vilobelimab, a complement 5a (C5a)-specific monoclonal antibody, reduced mortality in critically ill COVID-19 patients in a phase 3 multicentre, randomized, double-blind, placebo-controlled study. As part of t...

    Authors: Endry H. T. Lim, Alexander P. J. Vlaar, Sanne de Bruin, Simon Rückinger, Claus Thielert, Maria Habel, Renfeng Guo, Bruce P. Burnett, James Dickinson, Matthijs C. Brouwer, Niels C. Riedemann and Diederik van de Beek
    Citation: Intensive Care Medicine Experimental 2023 11:37
    Content type: Research Articles Published on:

  8. Intravenous oxygen therapeutics present an appealing option for improving arterial oxygenation in patients with acute hypoxemic respiratory failure, while limiting iatrogenic injury from conventional respirato...

    Authors: Jarrod M. Mosier, Saad Sammani, Carrie Kempf, Evan Unger and Joe G. N. Garcia
    Citation: Intensive Care Medicine Experimental 2023 11:33
    Content type: Research Articles Published on:

  9. Optimal anticoagulation strategies for COVID-19 patients with the acute respiratory distress syndrome (ARDS) on venovenous extracorporeal membrane oxygenation (VV ECMO) remain uncertain. A higher incidence of ...

    Authors: Daniel A. Hofmaenner, David Furfaro, Lennart C. Wild, Pedro David Wendel-Garcia, Elias Baedorf Kassis, Ameeka Pannu, Tobias Welte, Rolf Erlebach, Klaus Stahl, Edward Wilson Grandin, Christian Putensen, Reto A. Schuepbach, Shahzad Shaefi, Sascha David, Benjamin Seeliger and Christian Bode
    Citation: Intensive Care Medicine Experimental 2023 11:38
    Content type: Research Articles Published on:

  10. In intensive care, different central venous catheters (CVC) are often used for infusion of drugs. If a patient is treated with continuous renal replacement therapy (CRRT) a second catheter, a central venous di...

    Authors: Anna Bandert, Miklós Lipcsey, Robert Frithiof, Anders Larsson and David Smekal
    Citation: Intensive Care Medicine Experimental 2023 11:32
    Content type: Research Articles Published on:

  11. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality of patients with sepsis is high and largely unchanged throughout the past decades. Animal models ha...

    Authors: Finnja Marie Zurek-Leffers, Florian Lehmann, Laura Brabenec, Sebastian Kintrup, Katharina E. M. Hellenthal, Kira Mersjann, Felicia Kneifel, Michael Hessler, Philip-Helge Arnemann, Tim-Gerald Kampmeier, Christian Ertmer, Patrick Kellner and Nana-Maria Wagner
    Citation: Intensive Care Medicine Experimental 2023 11:31
    Content type: Research Articles Published on:

  12. Although vasopressor and sedative agents are commonly used within the intensive care unit to mediate systemic and cerebral physiology, the full impact such agents have on cerebrovascular reactivity remains unc...

    Authors: Logan Froese, Alwyn Gomez, Amanjyot Singh Sainbhi, Nuray Vakitbilir, Izabella Marquez, Fiorella Amenta, Kevin Y. Stein and Frederick A. Zeiler
    Citation: Intensive Care Medicine Experimental 2023 11:30
    Content type: Research Articles Published on:

  14. Mechanical power is a major contributor to lung injury and mortality in adults receiving mechanical ventilation. Recent advances in our understanding of mechanical power have allowed the different mechanical c...

    Authors: David G. Tingay, Hannah Naidu, Hamish D. Tingay, Prue M. Pereira-Fantini, Martin C. J. Kneyber and Tobias Becher
    Citation: Intensive Care Medicine Experimental 2023 11:28
    Content type: Hypothesis Published on:

  15. Invasive candidiasis (IC) is a severe and often fatal fungal infection that affects critically ill patients. The development of animal models that mimic human disease is essential for advancing our understandi...

    Authors: Anders Krifors, Anders Lignell, Miklós Lipcsey, Jan Sjölin and Markus Castegren
    Citation: Intensive Care Medicine Experimental 2023 11:27
    Content type: Methodologies Published on:

  16. Therapeutic plasma exchange (TPE) is a therapeutic intervention that separates plasma from blood cells to remove pathological factors or to replenish deficient factors. The use of TPE is increasing over the la...

    Authors: Sascha David, Lene Russell, Pedro Castro, Andry van de Louw, Lara Zafrani, Tasneem Pirani, Nathan D. Nielsen, Eric Mariotte, Bruno L. Ferreyro, Jan T. Kielstein, Luca Montini, Anne C. Brignier, Matthias Kochanek, Joan Cid, Chiara Robba, Ignacio Martin-Loeches…
    Citation: Intensive Care Medicine Experimental 2023 11:26
    Content type: Reviews Published on:

  17. Perioperative acute kidney injury (AKI) caused by ischemia–reperfusion (IR) is a significant contributor to mortality and morbidity after major surgery. Furosemide is commonly used in postoperative patients to...

    Authors: Olcay Dilken, Can Ince, Aysegul Kapucu, Paul M. Heeman and Bülent Ergin
    Citation: Intensive Care Medicine Experimental 2023 11:25
    Content type: Research Articles Published on:

  18. Cardiac index (CI) assessments are commonly used in critical care to define shock aetiology and guide resuscitation. Echocardiographic assessment is non-invasive and has high levels of agreement with thermodil...

    Authors: Prashant Parulekar, James Powys-Lybbe, Paul Bassett, Seb Roques, Mark Snazelle, Gemma Millen and Tim Harris
    Citation: Intensive Care Medicine Experimental 2023 11:23
    Content type: Research Articles Published on:

  19. Extensive animal investigation informed clinical practice regarding the harmful effects of high fractional inspired oxygen concentrations (FiO2s > 0.60). Since questions persist whether lower but still supraphysi...

    Authors: Samuel Minkove, Rhea Dhamapurkar, Xizhong Cui, Yan Li, Junfeng Sun, Diane Cooper, Peter Q. Eichacker and Parizad Torabi-Parizi
    Citation: Intensive Care Medicine Experimental 2023 11:22
    Content type: Reviews Published on:

  20. Mechanical ventilation has side effects such as ventilator-induced diaphragm dysfunction, resulting in prolonged intensive care unit length of stays. Artificially evoked diaphragmatic muscle contraction may po...

    Authors: Alessandro Panelli, Hermann Georges Bartels, Sven Krause, Michael André Verfuß, Aline Michèle Grimm, Niklas Martin Carbon, Julius J. Grunow, Diego Stutzer, Thomas Niederhauser, Laurent Brochard, Steffen Weber-Carstens and Stefan J. Schaller
    Citation: Intensive Care Medicine Experimental 2023 11:20
    Content type: Research Articles Published on:

  21. To investigate the effect of IV fluid resuscitation on endothelial glycocalyx (EG) shedding and activation of the vascular endothelium and inflammation.

    Authors: Stephen Macdonald, Erika Bosio, Gerben Keijzers, Sally Burrows, Moira Hibbs, Helen O’Donoghue, David Taylor, Ashes Mukherjee, Frances Kinnear, Lisa Smart, Juan-Carlos Ascencio-Lane, Edward Litton, John Fraser, Nathan I. Shapiro, Glenn Arendts and Daniel Fatovich
    Citation: Intensive Care Medicine Experimental 2023 11:21
    Content type: Research Articles Published on:

  22. The venous excess ultrasound (VExUS) score is a multi-organ Doppler approach to assess venous congestion. Despite growing use of VExUS in research and clinical practice, other veins can be visualized to assess...

    Authors: Jon-Emile S. Kenny, Ross Prager, Philippe Rola, Garett McCulloch, Joseph K. Eibl and Korbin Haycock
    Citation: Intensive Care Medicine Experimental 2023 11:19
    Content type: Research Articles Published on:

  24. The definition of partial resuscitative endovascular balloon occlusion of the aorta (pREBOA) is not yet determined and clinical markers of the degree of occlusion, metabolic effects and end-organ injury that a...

    Authors: Anna Stene Hurtsén, David T. McGreevy, Christina Karlsson, Claes G. Frostell, Tal M. Hörer and Kristofer F. Nilsson
    Citation: Intensive Care Medicine Experimental 2023 11:18
    Content type: Research Articles Published on:

  25. Assessment of the inferior vena cava (IVC) respiratory variation may be clinically useful for the estimation of fluid-responsiveness and venous congestion; however, imaging from subcostal (SC, sagittal) region...

    Authors: Filippo Sanfilippo, Luigi La Via, Veronica Dezio, Cristina Santonocito, Paolo Amelio, Giulio Genoese, Marinella Astuto and Alberto Noto
    Citation: Intensive Care Medicine Experimental 2023 11:15
    Content type: Research Articles Published on:

  26. Preload responsive postoperative patients with signs of inadequate organ perfusion are commonly assumed to be hypovolemic and therefore treated with fluids to increase preload. However, preload is influenced n...

    Authors: Anja Lindén, Svajunas Statkevicius, Johan Bonnevier and Peter Bentzer
    Citation: Intensive Care Medicine Experimental 2023 11:14
    Content type: Research Articles Published on:

  27. The decline in the downstream signal transduction pathway of anabolic hormone, insulin, could play a key role in the muscle atrophy and insulin resistance observed in patients with intensive care unit acquired...

    Authors: Julius J. Grunow, Thomas Gan, Heidrun Lewald, J. A. Jeevendra Martyn, Manfred Blobner and Stefan J. Schaller
    Citation: Intensive Care Medicine Experimental 2023 11:16
    Content type: Research Articles Published on:

  28. The effect of intravenous fluid (IVF) administration during cardiopulmonary resuscitation (CPR) is an unexplored factor that may improve cardiac output (CO) during CPR. The aim of this study was to determine t...

    Authors: Jennifer Lutz, Yosef Levenbrown, Md Jobayer Hossain, Anne Hesek, Kelly E. Massa, James P. Keith and Thomas H. Shaffer
    Citation: Intensive Care Medicine Experimental 2023 11:13
    Content type: Research Articles Published on:

  29. Detecting particle flow from the airways by a non-invasive analyzing technique might serve as an additional tool to monitor mechanical ventilation. In the present study, we used a customized particles in exhal...

    Authors: Ellen Broberg, Leif Pierre, Mohammed Fakhro, Malin Malmsjö, Sandra Lindstedt and Snejana Hyllén
    Citation: Intensive Care Medicine Experimental 2023 11:12
    Content type: Research Articles Published on:

  30. Sepsis is a syndromic response to infection and is frequently a final common pathway to death from many infectious diseases worldwide. The complexity and high heterogeneity of sepsis hinder the possibility to ...

    Authors: Aina Areny-Balagueró, Anna Solé-Porta, Marta Camprubí-Rimblas, Elena Campaña-Duel, Adrián Ceccato, Anna Roig, Daniel Closa and Antonio Artigas
    Citation: Intensive Care Medicine Experimental 2023 11:11
    Content type: Reviews Published on:

  31. Bioactive adrenomedullin (bio-ADM) is a vasoactive peptide with a key role in reducing vascular hyperpermeability and improving endothelial stability during infection, but it also has vasodilatory properties. ...

    Authors: Patrik Johnsson, Andrea Fredriksson, Christer Tung, Hans Friberg and Attila Frigyesi
    Citation: Intensive Care Medicine Experimental 2023 11:10
    Content type: Research Articles Published on:

  32. The role of upper airways microbiota and its association with ventilator-associated pneumonia (VAP) development in mechanically ventilated (MV) patients is unclear. Taking advantage of data collected in a pros...

    Authors: Laura Alagna, Leonardo Mancabelli, Federico Magni, Liliane Chatenoud, Gabriele Bassi, Silvia Del Bianco, Roberto Fumagalli, Francesca Turroni, Davide Mangioni, Guglielmo M. Migliorino, Christian Milani, Antonio Muscatello, Giovanni Nattino, Edoardo Picetti, Riccardo Pinciroli, Sandra Rossi…
    Citation: Intensive Care Medicine Experimental 2023 11:17
    Content type: Research Articles Published on:

  33. Divergence between deterioration to life-threatening COVID-19 or clinical improvement occurs for most within the first 14 days of symptoms. Life-threatening COVID-19 shares clinical similarities with Macrophag...

    Authors: Syed M. T. Nasser, Anas A. Rana, Rainer Doffinger, Andreas Kafizas, Tauseef A. Khan and Shuaib Nasser
    Citation: Intensive Care Medicine Experimental 2023 11:9
    Content type: Research Articles Published on:

  34. Assessing measurement error in alveolar recruitment on computed tomography (CT) is of paramount importance to select a reliable threshold identifying patients with high potential for alveolar recruitment and t...

    Authors: Ludmilla Penarrubia, Aude Verstraete, Maciej Orkisz, Eduardo Davila, Loic Boussel, Hodane Yonis, Mehdi Mezidi, Francois Dhelft, William Danjou, Alwin Bazzani, Florian Sigaud, Sam Bayat, Nicolas Terzi, Mehdi Girard, Laurent Bitker, Emmanuel Roux…
    Citation: Intensive Care Medicine Experimental 2023 11:8
    Content type: Research Articles Published on:

  35. Veno-venous extracorporeal membrane oxygenation (V–V ECMO) has an established evidence base in acute respiratory distress syndrome (ARDS) and has seen exponential growth in its use over the past decades. Howev...

    Authors: Patrick Duncan Collins, Lorenzo Giosa, Valentina Camarda and Luigi Camporota
    Citation: Intensive Care Medicine Experimental 2023 11:7
    Content type: Reviews Published on:

  36. The human gastrointestinal tract harbours a complex multi-kingdom community known as the microbiome. Dysbiosis refers to its disruption and is reportedly extreme in acute critical illness yet its clinical implica...

    Authors: Tess Evans, Umar Ali, Ryan Anderton, Edward Raby, Laurens Manning and Edward Litton
    Citation: Intensive Care Medicine Experimental 2023 11:6
    Content type: Research Articles Published on:

  38. To date cardiac arrest (CA) remains a frequent cause of morbidity and mortality: despite advances in cardiopulmonary resuscitation (CPR), survival is still burdened by hypoxic–ischemic brain injury (HIBI), and...

    Authors: Elisabetta Roberti, Giovanni Chiarini, Nicola Latronico, Enrica Chiara Adami, Chiara Plotti, Elisa Bonetta, Federica Magri and Frank Anthony Rasulo
    Citation: Intensive Care Medicine Experimental 2023 11:4
    Content type: Reviews Published on:

  39. Atrial fibrillation (AF) is the most common cardiac arrhythmia in the intensive care unit and is associated with increased morbidity and mortality. New-onset atrial fibrillation (NOAF) is often initially parox...

    Authors: Brian Chen, David M. Maslove, Jeffrey D. Curran, Alexander Hamilton, Philip R. Laird, Parvin Mousavi and Stephanie Sibley
    Citation: Intensive Care Medicine Experimental 2023 11:2
    Content type: Methodologies Published on:

  40. In refractory out-of-hospital cardiac arrest, transportation to hospital with continuous chest compressions (CCC) from a chest compression device and ventilation with 100% oxygen through an advanced airway is ...

    Authors: Jukka Kopra, Erik Litonius, Pirkka T. Pekkarinen, Merja Laitinen, Juho A. Heinonen, Luca Fontanelli, Tomi P. Mäkiaho and Markus B. Skrifvars
    Citation: Intensive Care Medicine Experimental 2023 11:3
    Content type: Research Articles Published on:

  42. Hyper-inflammatory syndrome in children and young adult occur 2–6 weeks after COVID-19 infection or closed contact with COVID-19 persons. In this study, the laboratory data and echocardiography and abdominal u...

    Authors: Payman Sadeghi, Mojtaba Gorji, Raheleh Assari, Fatemeh Tahghighi, Seyed Reza Raeeskarami and Vahid Ziaee
    Citation: Intensive Care Medicine Experimental 2022 10:56
    Content type: Research Articles Published on:

  44. Brain tissue oxygen tension (PbtO2) and cerebrovascular pressure reactivity monitoring have emerged as potential modalities to individualize care in moderate and severe traumatic brain injury (TBI). The relations...

    Authors: Alwyn Gomez, Mypinder Sekhon, Donald Griesdale, Logan Froese, Eleen Yang, Eric P. Thelin, Rahul Raj, Marcel Aries, Clare Gallagher, Francis Bernard, Andreas H. Kramer and Frederick A. Zeiler
    Citation: Intensive Care Medicine Experimental 2022 10:54
    Content type: Research Articles Published on:

  45. Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combi...

    Authors: Denise Battaglini, Adriana Lopes da Silva, Nathane Santanna Felix, Gisele Rodrigues, Mariana Alves Antunes, Nazareth Novaes Rocha, Vera Luiza Capelozzi, Marcelo Marcos Morales, Fernanda Ferreira Cruz, Chiara Robba, Pedro Leme Silva, Paolo Pelosi and Patricia Rieken Macedo Rocco
    Citation: Intensive Care Medicine Experimental 2022 10:53
    Content type: Research Articles Published on:

  46. Continuous measurement of urinary PO2 (PuO2) is being applied to indirectly monitor renal medullary PO2. However, when applied to critically ill patients with shock, its measurement may be affected by changes in ...

    Authors: Eduardo A. Osawa, Salvatore L. Cutuli, Fumitaka Yanase, Naoya Iguchi, Laurent Bitker, Alexandre T. Maciel, Yugeesh R. Lankadeva, Clive N. May, Roger G. Evans, Glenn M. Eastwood and Rinaldo Bellomo
    Citation: Intensive Care Medicine Experimental 2022 10:52
    Content type: Research Articles Published on:

  47. Fluid resuscitation is crucial in the initial management of sepsis; however, little is known about the serial changes and overall distribution of fluids administered into the body. To identify the feasibility ...

    Authors: Hwain Jeong, Inwon Park, Jae Hyuk Lee, Dongsung Kim, Sumin Baek, Seonghye Kim and You Hwan Jo
    Citation: Intensive Care Medicine Experimental 2022 10:51
    Content type: Research Articles Published on:

  48. This scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

    Authors: Senta Jorinde Raasveld, Carolien Volleman, Alain Combes, Lars Mikael Broman, Fabio Silvio Taccone, Elma Peters, Sanne ten Berg, Charissa E. van den Brom, Holger Thiele, Roberto Lorusso, José P. S. Henriques and Alexander P. J. Vlaar
    Citation: Intensive Care Medicine Experimental 2022 10:50
    Content type: Reviews Published on:

  49. The gut has been hypothesized to be a protagonist tissue in multiple organ dysfunction syndrome (MODS) for the past three decades. Gastric reactance (XL) is a potential perfusion marker derived from gastric im...

    Authors: María M. Godinez-Garcia, Adrian Soto-Mota, Jorge Catrip, Ruben Gaitan, Ma del C. Lespron, Francisco J. Molina, Miguel A. Falcón, Alberto Aranda, Carlos A. Tena, Pedro Zamudio, Ivan Briseño, Rolando Alvarez and Yazmin Guillen
    Citation: Intensive Care Medicine Experimental 2022 10:49
    Content type: Research Articles Published on:

  50. Authors: Francesca M. Stefanizzi, Lu Zhang, Antonio Salgado-Somoza, Josef Dankiewicz, Pascal Stammet, Christian Hassager, Matthew P. Wise, Hans Friberg, Tobias Cronberg, Alexander Hundt, Jesper Kjaergaard, Niklas Nielsen and Yvan Devaux
    Citation: Intensive Care Medicine Experimental 2022 10:48
    Content type: Correction Published on:

    The original article was published in Intensive Care Medicine Experimental 2022 10:41

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  • ISSN: 2197-425X (electronic)