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PEEP titration: the effect of prone position and abdominal pressure in an ARDS model
Joseph C. Keenan, Gustavo A. Cortes-Puentes, Lei Zhang, Alex B. Adams, David J. Dries and John J. Marini
Intensive Care Medicine Experimental 2018 6:3
Published on: 30 January 2018

Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen
David H. Jang, Utsha G. Khatri, Brenna P. Shortal, Matthew Kelly, Kevin Hardy, David S. Lambert and David M. Eckmann
Intensive Care Medicine Experimental 2018 6:4
Published on: 30 January 2018

Extracorporeal membrane oxygenation line-associated complications: in vitro testing of cyanoacrylate tissue adhesive and securement devices to prevent infection and dislodgement
Taressa Bull, Amanda Corley, Danielle J. Smyth, David J. McMillan, Kimble R. Dunster and John F. Fraser
Intensive Care Medicine Experimental 2018 6:6
Published on: 12 March 2018

A high-flow nasal cannula system with relatively low flow effectively washes out CO2 from the anatomical dead space in a sophisticated respiratory model made by a 3D printer
Yu Onodera, Ryo Akimoto, Hiroto Suzuki, Masayuki Okada, Masaki Nakane and Kaneyuki Kawamae
Intensive Care Medicine Experimental 2018 6:7
Published on: 15 March 2018

Preliminary experience on the safety and tolerability of mechanical “insufflation-exsufflation” in subjects with artificial airway
Miguel Sánchez-García, Passio Santos, Gema Rodríguez-Trigo, Fernando Martínez-Sagasti, Tomás Fariña-González, Ángela del Pino-Ramírez, Carlos Cardenal-Sánchez, Beatriz Busto-González, Mónica Requesens-Solera, Mercedes Nieto-Cabrera, Francisco Romero-Romero and Antonio Núñez-Reiz
Intensive Care Medicine Experimental 2018 6:8
Published on: 3 April 2018

Positional effects on the distributions of ventilation and end-expiratory gas volume in the asymmetric chest—a quantitative lung computed tomographic analysis
Gustavo A. Cortes-Puentes, Kenneth E. Gard, Alexander B. Adams, David J. Dries, Michael Quintel, Richard A. Oeckler, Luciano Gattinoni and John J. Marini
Intensive Care Medicine Experimental 2018 6:9
Published on: 10 April 2018

Bias flow rate and ventilation efficiency during adult high-frequency oscillatory ventilation: a lung model study
Osamu Nagano, Tetsuya Yumoto, Atsunori Nishimatsu, Shunsuke Kanazawa, Takahisa Fujita, Sunao Asaba and Hideo Yamanouchi
Intensive Care Medicine Experimental 2018 6:11
Published on: 19 April 2018

A vascular endothelial growth factor receptor gene variant is associated with susceptibility to acute respiratory distress syndrome
Natalia Hernandez-Pacheco, Beatriz Guillen-Guio, Marialbert Acosta-Herrera, Maria Pino-Yanes, Almudena Corrales, Alfonso Ambrós, Leonor Nogales, Arturo Muriel, Elena González-Higueras, Francisco J. Diaz-Dominguez, Elizabeth Zavala, Javier Belda, Shwu-Fan Ma, Jesús Villar and Carlos Flores
Intensive Care Medicine Experimental 2018 6:16
Published on: 9 July 2018

A new way of monitoring mechanical ventilation by measurement of particle flow from the airways using Pexa method in vivo and during ex vivo lung perfusion in DCD lung transplantation
Ellen Broberg, Martiné Wlosinska, Lars Algotsson, Anna-Carin Olin, Darcy Wagner, Leif Pierre and Sandra Lindstedt
Intensive Care Medicine Experimental 2018 6:18
Published on: 27 July 2018

Evaluation of end-tidal carbon dioxide gradient as a predictor of volume responsiveness in spontaneously breathing healthy adults
María C. Arango-Granados, Virginia Zarama Córdoba, Andrés M. Castro Llanos and Luis A. Bustamante Cristancho
Intensive Care Medicine Experimental 2018 6:21
Published on: 30 July 2018

A mathematical model of CO2, O2 and N2 exchange during venovenous extracorporeal membrane oxygenation
Christopher John Joyce, Kiran Shekar and David Andrew Cook
Intensive Care Medicine Experimental 2018 6:25
Published on: 9 August 2018

Advanced modes of mechanical ventilation and optimal targeting schemes
Matthias van der Staay and Robert L. Chatburn
Intensive Care Medicine Experimental 2018 6:30
Published on: 22 August 2018

Bench Validation of a Compact Low-Flow CO2 Removal Device
Alexandra G. May, R. Garrett Jeffries, Brian J. Frankowski, Greg W. Burgreen and William J. Federspiel
Intensive Care Medicine Experimental 2018 6:34
Published on: 24 September 2018


Personalizing mechanical ventilation according to physiologic parameters to stabilize alveoli and minimize ventilator induced lung injury (VILI)
Gary F. Nieman, Joshua Satalin, Penny Andrews, Hani Aiash, Nader M. Habashi and Louis A. Gatto
Intensive Care Medicine Experimental 2017 5:8
Published on: 2 February 2017

The respiratory pressure—abdominal volume curve in a porcine model
Adrian Regli, Bart Leon De Keulenaer, Bhajan Singh, Lisen Emma Hockings, Bill Noffsinger and Peter Vernon van Heerden
Intensive Care Medicine Experimental 2017 5:11
Published on: 28 February 2017

Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice
Tommaso Mauri, Vanessa Zambelli, Claudia Cappuzzello, Giacomo Bellani, Erica Dander, Marina Sironi, Vittoria Castiglioni, Andrea Doni, Alberto Mantovani, Andrea Biondi, Cecilia Garlanda, Giovanna D’amico and Antonio Pesenti
Intensive Care Medicine Experimental 2017 5:13
Published on: 6 March 2017

The role of calpains in ventilator-induced diaphragm atrophy
Xiaoping Zhu, Hieronymus W. H. van Hees, Leo Heunks, Feifei Wang, Lei Shao, Jiaru Huang, Lei Shi and Shaolin Ma
Intensive Care Medicine Experimental 2017 5:14
Published on: 14 March 2017

Ultra-low-dose sequential computed tomography for quantitative lung aeration assessment—a translational study
Lorenzo Ball, Anja Braune, Francesco Corradi, Claudia Brusasco, Alessandro Garlaschi, Thomas Kiss, Thomas Bluth, Francesca Simonassi, Alice Bergamaschi, Jörg Kotzerke, Marcus J. Schultz, Marcelo Gama de Abreu and Paolo Pelosi
Intensive Care Medicine Experimental 2017 5:19
Published on: 4 April 2017

The effects of hyperoxia on microvascular endothelial cell proliferation and production of vaso-active substances
Ilias Attaye, Yvo M. Smulders, Monique C. de Waard, Heleen M. Oudemans-van Straaten, Bob Smit, Michiel H. Van Wijhe, Rene J. Musters, Pieter Koolwijk and Angelique M. E. Spoelstra–de Man
Intensive Care Medicine Experimental 2017 5:22
Published on: 13 April 2017

The role of high airway pressure and dynamic strain on ventilator-induced lung injury in a heterogeneous acute lung injury model
Sumeet V. Jain, Michaela Kollisch-Singule, Joshua Satalin, Quinn Searles, Luke Dombert, Osama Abdel-Razek, Natesh Yepuri, Antony Leonard, Angelika Gruessner, Penny Andrews, Fabeha Fazal, Qinghe Meng, Guirong Wang, Louis A. Gatto, Nader M. Habashi and Gary F. Nieman
Intensive Care Medicine Experimental 2017 5:25
Published on: 12 May 2017

Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes
Hendrik J. F. Helmerhorst, Laura R. A. Schouten, Gerry T. M. Wagenaar, Nicole P. Juffermans, Joris J. T. H. Roelofs, Marcus J. Schultz, Evert de Jonge and David J. van Westerloo
Intensive Care Medicine Experimental 2017 5:27
Published on: 26 May 2017

Whole blood microRNA markers are associated with acute respiratory distress syndrome
Zhaozhong Zhu, Liming Liang, Ruyang Zhang, Yongyue Wei, Li Su, Paula Tejera, Yichen Guo, Zhaoxi Wang, Quan Lu, Andrea A. Baccarelli, Xi Zhu, Ednan K. Bajwa, B. Taylor Thompson, Guo-Ping Shi and David C. Christiani
Intensive Care Medicine Experimental 2017 5:38
Published on: 30 August 2017

Protective ventilation reduces Pseudomonas aeruginosa growth in lung tissue in a porcine pneumonia model
Jesper Sperber, Axel Nyberg, Miklos Lipcsey, Åsa Melhus, Anders Larsson, Jan Sjölin and Markus Castegren
Intensive Care Medicine Experimental 2017 5:40
Published on: 31 August 2017

Effects of regional perfusion block in healthy and injured lungs
Barbara Cambiaghi, Francesco Vasques, Onnen Mörer, Christian Ritter, Tommaso Mauri, Nils Kunze-Szikszay, Karin Holke, Francesca Collino, Giorgia Maiolo, Francesca Rapetti, Elias Schulze-Kalthoff, Tommaso Tonetti, Günter Hahn, Michael Quintel and Luciano Gattinoni
Intensive Care Medicine Experimental 2017 5:46
Published on: 13 October 2017


The 30-year evolution of airway pressure release ventilation (APRV)
Sumeet V. Jain, Michaela Kollisch-Singule, Benjamin Sadowitz, Luke Dombert, Josh Satalin, Penny Andrews, Louis A. Gatto, Gary F. Nieman and Nader M. Habashi
Intensive Care Medicine Experimental 2016 4:11
Published on: 20 May 2016

Lung stress, strain, and energy load: engineering concepts to understand the mechanism of ventilator-induced lung injury (VILI)
Gary F. Nieman, Joshua Satalin, Penny Andrews, Nader M. Habashi and Louis A. Gatto
Intensive Care Medicine Experimental 2016 4:16
Published on: 18 June 2016

Transpulmonary and pleural pressure in a respiratory system model with an elastic recoiling lung and an expanding chest wall
Per Persson, Stefan Lundin and Ola Stenqvist
Intensive Care Medicine Experimental 2016 4:26
Published on: 20 September 2016

Exploring alternative routes for oxygen administration
Elisa Damiani, Alex Dyson, Lucia Zacchetti, Abele Donati and Mervyn Singer
Intensive Care Medicine Experimental 2016 4:34
Published on: 10 October 2016

Comparison between effects of pressure support and pressure-controlled ventilation on lung and diaphragmatic damage in experimental emphysema
Gisele de A. Padilha, Lucas F. B. Horta, Lillian Moraes, Cassia L. Braga, Milena V. Oliveira, Cíntia L. Santos, Isalira P. Ramos, Marcelo M. Morales, Vera Luiza Capelozzi, Regina C. S. Goldenberg, Marcelo Gama de Abreu, Paolo Pelosi, Pedro L. Silva and Patricia R. M. Rocco
Intensive Care Medicine Experimental 2016 4:35
Published on: 19 October 2016


Effect of body position on ventilation distribution during PEEP titration in a porcine model of acute lung injury using advanced respiratory monitoring and electrical impedance tomography
Klaus Pfurtscheller, Stefan Ring, Elisabeth Beran, Erich Sorantin, Joachim Zobel, David Ganster, Alexander Avian and Gerfried Zobel
Intensive Care Medicine Experimental 2015 3:3
Published on: 31 January 2015

Systolic left ventricular function is preserved during therapeutic hypothermia, also during increases in heart rate with impaired diastolic filling
Viesturs Kerans, Andreas Espinoza, Helge Skulstad, Per Steinar Halvorsen, Thor Edvardsen and Jan Frederik Bugge
Intensive Care Medicine Experimental 2015 3:6
Published on: 24 February 2015

Angiotensin-(1-7) improves oxygenation, while reducing cellular infiltrate and fibrosis in experimental Acute Respiratory Distress Syndrome
Vanessa Zambelli, Giacomo Bellani, Roberto Borsa, Federico Pozzi, Alice Grassi, Margherita Scanziani, Vittoria Castiglioni, Serge Masson, Alessandra Decio, John G Laffey, Roberto Latini and Antonio Pesenti
Intensive Care Medicine Experimental 2015 3:8
Published on: 27 February 2015

An authentic animal model of the very preterm infant on nasal continuous positive airway pressure
Peter A Dargaville, Anna Lavizzari, Priscila Padoin, Don Black, Elroy Zonneveld, Elizabeth Perkins, Magdy Sourial, Anushi E Rajapaksa, Peter G Davis, Stuart B Hooper, Timothy JM Moss, Graeme R Polglase and David G Tingay
Intensive Care Medicine Experimental 2015 3:13
Published on: 29 April 2015

Alveolar instability (atelectrauma) is not identified by arterial oxygenation predisposing the development of an occult ventilator-induced lung injury
Penny L Andrews, Benjamin Sadowitz, Michaela Kollisch-Singule, Joshua Satalin, Shreyas Roy, Kathy Snyder, Louis A Gatto, Gary F Nieman and Nader M Habashi
Intensive Care Medicine Experimental 2015 3:16
Published on: 9 June 2015

Prone position ameliorates lung elastance and increases functional residual capacity independently from lung recruitment
Alessandro Santini, Alessandro Protti, Thomas Langer, Beatrice Comini, Massimo Monti, Cristina Carin Sparacino, Daniele Dondossola and Luciano Gattinoni
Intensive Care Medicine Experimental 2015 3:17
Published on: 11 June 2015

Atelectasis causes alveolar hypoxia-induced inflammation during uneven mechanical ventilation in rats
Kentaro Tojo, Yusuke Nagamine, Takuya Yazawa, Takahiro Mihara, Yasuko Baba, Shuhei Ota, Takahisa Goto and Kiyoyasu Kurahashi
Intensive Care Medicine Experimental 2015 3:18
Published on: 19 June 2015

Tumor necrosis factor receptor 1 (TNFRI) for ventilator-associated pneumonia diagnosis by cytokine multiplex analysis
Ignacio Martin-Loeches, Lieuwe D. Bos, Pedro Povoa, Paula Ramirez, Marcus J. Schultz, Antoni Torres and Antonio Artigas
Intensive Care Medicine Experimental 2015 3:26
Published on: 16 September 2015

The role of dexamethasone in scorpion venom-induced deregulation of sodium and water transport in rat lungs
Ceila Maria Sant Ana Malaque, Ana Carolina de Bragança, Talita Rojas Sanches, Rildo Aparecido Volpini, Maria Heloisa Shimizu, Meire Ioshie Hiyane, Niels Olsen Saraiva Câmara, Antonio Carlos Seguro and Lucia Andrade
Intensive Care Medicine Experimental 2015 3:28
Published on: 21 September 2015

Mesenchymal stromal cells are more effective than the MSC secretome in diminishing injury and enhancing recovery following ventilator-induced lung injury
Mairead Hayes, Gerard F. Curley, Claire Masterson, James Devaney, Daniel O’Toole and John G. Laffey
Intensive Care Medicine Experimental 2015 3:29
Published on: 15 October 2015

Noradrenalin effectively rescues mice from blast lung injury caused by laser-induced shock waves
Hiroki Miyawaki, Daizoh Saitoh, Kohsuke Hagisawa, Midori Noguchi, Shunichi Sato, Manabu Kinoshita, Hiromi Miyazaki, Yasushi Satoh, Nahoko Harada and Toshihisa Sakamoto
Intensive Care Medicine Experimental 2015 3:32
Published on: 10 December 2015

Computational simulation indicates that moderately high-frequency ventilation can allow safe reduction of tidal volumes and airway pressures in ARDS patients
Wenfei Wang, Anup Das, Oanna Cole, Marc Chikhani, Jonathan G. Hardman and Declan G. Bates
Intensive Care Medicine Experimental 2015 3:33
Published on: 10 December 2015

Lung anatomy, energy load, and ventilator-induced lung injury
Alessandro Protti, Davide T. Andreis, Marta Milesi, Giacomo E. Iapichino, Massimo Monti, Beatrice Comini, Paola Pugni, Valentina Melis, Alessandro Santini, Daniele Dondossola, Stefano Gatti, Luciano Lombardi, Emiliano Votta, Eleonora Carlesso and Luciano Gattinoni
Intensive Care Medicine Experimental 2015 3:34
Published on: 15 December 2015

The effects of airway pressure release ventilation on respiratory mechanics in extrapulmonary lung injury
Michaela Kollisch-Singule, Bryanna Emr, Sumeet V. Jain, Penny Andrews, Joshua Satalin, Jiao Liu, Elizabeth Porcellio, Van Kenyon, Guirong Wang, William Marx, Louis A. Gatto, Gary F. Nieman and Nader M. Habashi
Intensive Care Medicine Experimental 2015 3:35
Published on: 22 December 2015


Unilateral mechanical asymmetry: positional effects on lung volumes and transpulmonary pressure
Gustavo A Cortes-Puentes, Kenneth Gard, Joseph C Keenan, Alexander Adams, David Dries and John J Marini
Intensive Care Medicine Experimental 2014 2:4
Published on: 5 February 2014

Mechanical ventilation with heliox in an animal model of acute respiratory distress syndrome
Charlotte J Beurskens, Hamid Aslami, Friso M de Beer, Joris JTH Roelofs, Margreeth B Vroom and Nicole P Juffermans
Intensive Care Medicine Experimental 2014 2:8
Published on: 6 February 2014

Administration of intrapulmonary sodium polyacrylate to induce lung injury for the development of a porcine model of early acute respiratory distress syndrome
William R Henderson, Julian Barnbrook, Paolo B Dominelli, Donald EG Griesdale, Tara Arndt, Yannick Molgat-Seon, Glen Foster, Gareth L Ackland, James Xu, Najib T Ayas and Andrew W Sheel
Intensive Care Medicine Experimental 2014 2:5
Published on: 26 February 2014

Reliability of the nitrogen washin-washout technique to assess end-expiratory lung volume at variable PEEP and tidal volumes
Jean-Christophe Richard, Céline Pouzot, Alfredo Morales Pinzón, Juan Sebastian Torres González, Maciej Orkisz, Bruno Neyran, Marcela Hernández Hoyos, Franck Lavenne and Claude Guerin
Intensive Care Medicine Experimental 2014 2:10
Published on: 9 April 2014

Assessment of ventilation inhomogeneity during mechanical ventilation using a rapid-response oxygen sensor-based oxygen washout method
Ido G Bikker, Wim Holland, Patricia Specht, Can Ince and Diederik Gommers
Intensive Care Medicine Experimental 2014 2:14
Published on: 16 April 2014

Moderately high frequency ventilation with a conventional ventilator allows reduction of tidal volume without increasing mean airway pressure
Ricardo Luiz Cordioli, Marcelo Park, Eduardo Leite Vieira Costa, Susimeire Gomes, Laurent Brochard, Marcelo Britto Passos Amato and Luciano Cesar Pontes Azevedo
Intensive Care Medicine Experimental 2014 2:13
Published on: 9 May 2014

Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury
Evangelos Kaniaris, Katerina Vaporidi, Eleni Vergadi, Emmanuel E Theodorakis, Eumorfia Kondili, Eleni Lagoudaki, Christos Tsatsanis and Dimitris Georgopoulos
Intensive Care Medicine Experimental 2014 2:15
Published on: 9 May 2014

Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis
Larissa Constantino, Renata Casagrande Gonçalves, Vinícius Renê Giombelli, Cristiane Damiani Tomasi, Francieli Vuolo, Luiza Wilges Kist, Giovanna Medeiros Tavares de Oliveira, Matheus Augusto de Bittencourt Pasquali, Maurício Reis Bogo, Thais Mauad, Adolfo Horn Jr, Karen V Melo, Christiane Fernandes, José Cláudio Fonseca Moreira, Cristiane Ritter and Felipe Dal-Pizzol
Intensive Care Medicine Experimental 2014 2:17
Published on: 23 May 2014

The receptor for advanced glycation end products in ventilator-induced lung injury
Maria T Kuipers, Hamid Aslami, Pieter Roel Tuinman, Anita M Tuip-de Boer, Geartsje Jongsma, Koenraad F van der Sluijs, Goda Choi, Esther K Wolthuis, Joris JTH Roelofs, Paul Bresser, Marcus J Schultz, Tom van der Poll and Catharina W Wieland
Intensive Care Medicine Experimental 2014 2:22
Published on: 2 August 2014

Can computer simulators accurately represent the pathophysiology of individual COPD patients?
Wenfei Wang, Anup Das, Tayyba Ali, Oanna Cole, Marc Chikhani, Mainul Haque, Jonathan G Hardman and Declan G Bates
Intensive Care Medicine Experimental 2014 2:23
Published on: 20 September 2014

Effect of PEEP on breath sound power spectra in experimental lung injury
Jukka Räsänen, Michael E Nemergut and Noam Gavriely
Intensive Care Medicine Experimental 2014 2:25
Published on: 16 October 2014

Validation of computed tomography for measuring lung weight
Alessandro Protti, Giacomo E Iapichino, Marta Milesi, Valentina Melis, Paola Pugni, Beatrice Comini, Massimo Cressoni and Luciano Gattinoni
Intensive Care Medicine Experimental 2014 2:31
Published on: 5 December 2014


IL-1β processing in mechanical ventilation-induced inflammation is dependent on neutrophil factors rather than caspase-1
Kim Timmermans, Selina EI van der Wal, Michiel Vaneker, Jeroen AWM van der Laak, Mihai G Netea, Peter Pickkers, Gert Jan Scheffer, Leo AB Joosten and Matthijs Kox
Intensive Care Medicine Experimental 2013 1:8
Published on: 29 October 2013

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