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Intensive Care Medicine Experimental

Table 3 Parameters of kidney function in the vehicle- ( n = 11) and HAM1101-treated ( n = 9) animals

From: Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock

 

Vehicle

HAM1101

p value

Urine output (μL·g−1·h−1)

4.4 (3.5, 16.5)

15.2 (13.9, 22.5)

0.033

Creatinine clearance (μL·min−1)

197 (110, 301)

400 (316, 509)

0.006

Creatinine (μg·mL−1)

1.83 (1.52, 3.04)

1.28 (1.20, 1.52)

0.010

Urea (μg·mL−1)

378 (268, 513)

175 (101, 184)

0.004

NGAL (μg·mL−1)

16 (15, 20)

11 (10, 13)

0.008

  1. Blood concentrations were measured in samples taken at the end of the experiment. NGAL, neutrophil gelatinase-associated lipocalin. All data are median (quartiles).
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