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  1. Research

    Assessment of endothelial cell function and physiological microcirculatory reserve by video microscopy using a topical acetylcholine and nitroglycerin challenge

    Assessment of the microcirculation is a promising target for the hemodynamic management of critically ill patients. However, just as the sole reliance on macrocirculatory parameters, single static parameters o...

    Matthias Peter Hilty, Jacqueline Pichler, Bulent Ergin, Urs Hefti, Tobias Michael Merz, Can Ince and Marco Maggiorini

    Intensive Care Medicine Experimental 2017 5:26

    Published on: 18 May 2017

  2. Research

    The role of high airway pressure and dynamic strain on ventilator-induced lung injury in a heterogeneous acute lung injury model

    Acute respiratory distress syndrome causes a heterogeneous lung injury with normal and acutely injured lung tissue in the same lung. Improperly adjusted mechanical ventilation can exacerbate ARDS causing a sec...

    Sumeet V. Jain, Michaela Kollisch-Singule, Joshua Satalin, Quinn Searles, Luke Dombert, Osama Abdel-Razek, Natesh Yepuri, Antony Leonard, Angelika Gruessner, Penny Andrews, Fabeha Fazal, Qinghe Meng, Guirong Wang, Louis A. Gatto, Nader M. Habashi and Gary F. Nieman

    Intensive Care Medicine Experimental 2017 5:25

    Published on: 12 May 2017

  3. Research

    Systemic and microcirculatory effects of blood transfusion in experimental hemorrhagic shock

    The microvascular reperfusion injury after retransfusion has not been completely characterized. Specifically, the question of heterogeneity among different microvascular beds needs to be addressed. In addition...

    Gonzalo Ferrara, Vanina S. Kanoore Edul, Héctor S. Canales, Enrique Martins, Carlos Canullán, Gastón Murias, Mario O. Pozo, Juan F. Caminos Eguillor, María G. Buscetti, Can Ince and Arnaldo Dubin

    Intensive Care Medicine Experimental 2017 5:24

    Published on: 21 April 2017

  4. Research

    Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis

    Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing se...

    Victor Jeger, Mattia Arrigo, Florian F. Hildenbrand, Daniel Müller, Paulin Jirkof, Till Hauffe, Burkhardt Seifert, Margarete Arras, Donat R. Spahn, Dominique Bettex and Alain Rudiger

    Intensive Care Medicine Experimental 2017 5:23

    Published on: 20 April 2017

  5. Research

    The effects of hyperoxia on microvascular endothelial cell proliferation and production of vaso-active substances

    Hyperoxia, an arterial oxygen pressure of more than 100 mmHg or 13% O2, frequently occurs in hospitalized patients due to administration of supplemental oxygen. Increasing evidence suggests that hyperoxia induces...

    Ilias Attaye, Yvo M. Smulders, Monique C. de Waard, Heleen M. Oudemans-van Straaten, Bob Smit, Michiel H. Van Wijhe, Rene J. Musters, Pieter Koolwijk and Angelique M. E. Spoelstra–de Man

    Intensive Care Medicine Experimental 2017 5:22

    Published on: 13 April 2017

  6. Research

    Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of sepsis

    Recognition of cardiomyopathy in sepsis can be challenging due to the limitations of conventional measures such as ejection fraction (EF) and fractional shortening (FS) in the context of variable preload and a...

    Bereketeab Haileselassie, Erik Su, Iraklis Pozios, Diego F. Niño, Hongyun Liu, Dai-Yin Lu, Ioannis Ventoulis, William B. Fulton, Chhinder P. Sodhi, David Hackam, Brian O’Rourke and Theodore Abraham

    Intensive Care Medicine Experimental 2017 5:21

    Published on: 12 April 2017

  7. Research

    Extracorporeal CO2 removal by hemodialysis: in vitro model and feasibility

    Critically ill patients with acute respiratory distress syndrome and acute exacerbations of chronic obstructive pulmonary disease often develop hypercapnia and require mechanical ventilation. Extracorporeal ca...

    Alexandra G. May, Ayan Sen, Matthew E. Cove, John A. Kellum and William J. Federspiel

    Intensive Care Medicine Experimental 2017 5:20

    Published on: 7 April 2017

  8. Research

    Ultra-low-dose sequential computed tomography for quantitative lung aeration assessment—a translational study

    Quantitative lung computed tomography (CT) provides fundamental information about lung aeration in critically ill patients. We tested a scanning protocol combining reduced number of CT slices and tube current,...

    Lorenzo Ball, Anja Braune, Francesco Corradi, Claudia Brusasco, Alessandro Garlaschi, Thomas Kiss, Thomas Bluth, Francesca Simonassi, Alice Bergamaschi, Jörg Kotzerke, Marcus J. Schultz, Marcelo Gama de Abreu and Paolo Pelosi

    Intensive Care Medicine Experimental 2017 5:19

    Published on: 4 April 2017

  9. Research

    Granulocyte and monocyte adsorptive apheresis ameliorates sepsis in rats

    Overwhelming activation of granulocytes and monocytes is central to inflammatory responses during sepsis. Granulocyte and monocyte adsorptive apheresis (GMA) is an extracorporeal leukocyte apheresis device fil...

    Shuai Ma, Qingqing Xu, Bo Deng, Yin Zheng, Hongyan Tian, Li Wang and Feng Ding

    Intensive Care Medicine Experimental 2017 5:18

    Published on: 24 March 2017

  10. Research

    Cardiovascular disease and resuscitated septic shock lead to the downregulation of the H2S-producing enzyme cystathionine-γ-lyase in the porcine coronary artery

    Downregulation of the hydrogen sulfide (H2S)-producing enzymes cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and/or 3-mercaptopyruvate sulfurtransferase (3-MST) is associated with chronic cardiovas...

    Tamara Merz, Tatjana Stenzel, Benedikt Nußbaum, Martin Wepler, Csaba Szabo, Rui Wang, Peter Radermacher and Oscar McCook

    Intensive Care Medicine Experimental 2017 5:17

    Published on: 21 March 2017

  11. Research

    Extracellular superoxide dismutase is necessary to maintain renal blood flow during sepsis development

    Extracellular superoxide dismutase (ECSOD) protects nitric oxide (NO) bioavailability by decreasing superoxide levels and preventing peroxynitrite generation, which is important in maintaining renal blood flow...

    Larissa Constantino, Letícia Selinger Galant, Francieli Vuolo, Karla Lorena Guarido, Luiza Wilges Kist, Giovanna Medeiros Tavares de Oliveira, Matheus Augusto de Bittencourt Pasquali, Cláudio Teodoro de Souza, José Eduardo da Silva-Santos, Maurício Reis Bogo, José Cláudio Fonseca Moreira, Cristiane Ritter and Felipe Dal-Pizzol

    Intensive Care Medicine Experimental 2017 5:15

    Published on: 16 March 2017

  12. Research

    The role of calpains in ventilator-induced diaphragm atrophy

    Controlled mechanical ventilation (CMV) is associated with diaphragm dysfunction. Dysfunction results from muscle atrophy and injury of diaphragm muscle fibers. Enhanced proteolysis and reduced protein synthes...

    Xiaoping Zhu, Hieronymus W. H. van Hees, Leo Heunks, Feifei Wang, Lei Shao, Jiaru Huang, Lei Shi and Shaolin Ma

    Intensive Care Medicine Experimental 2017 5:14

    Published on: 14 March 2017

  13. Research

    Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice

    Mesenchymal stem cells (MSCs) might act as fine-tuners of inflammation during acute lung injury. We assessed the effects of adoptive transfer of MSCs in acid aspiration acute lung injury and explored the role ...

    Tommaso Mauri, Vanessa Zambelli, Claudia Cappuzzello, Giacomo Bellani, Erica Dander, Marina Sironi, Vittoria Castiglioni, Andrea Doni, Alberto Mantovani, Andrea Biondi, Cecilia Garlanda, Giovanna D’amico and Antonio Pesenti

    Intensive Care Medicine Experimental 2017 5:13

    Published on: 6 March 2017

  14. Research

    Experimental assessment of oxygen homeostasis during acute hemodilution: the integrated role of hemoglobin concentration and blood pressure

    Low hemoglobin concentration (Hb) and low mean arterial blood pressure (MAP) impact outcomes in critically ill patients. We utilized an experimental model of “normotensive” vs. “hypotensive” acute hemodilution...

    Tiffanie Kei, Nikhil Mistry, Albert K. Y. Tsui, Elaine Liu, Stephen Rogers, Allan Doctor, David F. Wilson, Jean-Francois Desjardins, Kim Connelly, C. David Mazer and Gregory M. T. Hare

    Intensive Care Medicine Experimental 2017 5:12

    Published on: 1 March 2017

  15. Research

    The respiratory pressure—abdominal volume curve in a porcine model

    Increasing intra-abdominal volume (IAV) can lead to intra-abdominal hypertension (IAH) or abdominal compartment syndrome. Both are associated with raised morbidity and mortality. IAH can increase airway pressu...

    Adrian Regli, Bart Leon De Keulenaer, Bhajan Singh, Lisen Emma Hockings, Bill Noffsinger and Peter Vernon van Heerden

    Intensive Care Medicine Experimental 2017 5:11

    Published on: 28 February 2017

  16. Research

    Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality

    The purposes of this study are to examine if the human glucocorticoid receptor (hGR) isoform-α mRNA and hGR protein expressions are deficient in the acute phase of sepsis (S) compared to systemic inflammatory ...

    Konstantinos Vardas, Stavroula Ilia, Amalia Sertedaki, Evangelia Charmandari, Efrossini Briassouli, Dimitris Goukos, Kleovoulos Apostolou, Katerina Psarra, Efthimia Botoula, Stylianos Tsagarakis, Eleni Magira, Christina Routsi, Constantine A. Stratakis, Serafim Nanas and George Briassoulis

    Intensive Care Medicine Experimental 2017 5:10

    Published on: 21 February 2017

  17. Letter to the Editor

    ‘In a dark place, we find ourselves’: light intensity in critical care units

    Intensive care units provide specialised care for critically ill patients around the clock. However, intensive care unit patients have disrupted circadian rhythms. Furthermore, disrupted circadian rhythms are ...

    Hannah J. Durrington, Richard Clark, Ruari Greer, Franck P. Martial, John Blaikley, Paul Dark, Robert J. Lucas and David W. Ray

    Intensive Care Medicine Experimental 2017 5:9

    Published on: 7 February 2017

  18. Review

    Personalizing mechanical ventilation according to physiologic parameters to stabilize alveoli and minimize ventilator induced lung injury (VILI)

    It has been shown that mechanical ventilation in patients with, or at high-risk for, the development of acute respiratory distress syndrome (ARDS) can be a double-edged sword. If the mechanical breath is impro...

    Gary F. Nieman, Joshua Satalin, Penny Andrews, Hani Aiash, Nader M. Habashi and Louis A. Gatto

    Intensive Care Medicine Experimental 2017 5:8

    Published on: 2 February 2017

  19. Research

    Baseline thrombospondin-1 concentrations are not associated with mortality in septic patients: a single-center cohort study on the intensive care unit

    The initial phase of sepsis is characterized by hyperinflammation. Levels of thrombospondin-1 (TSP-1) rise rapidly during acute inflammation. The purpose of this clinical study was to study the association bet...

    Ruben J. van der Wekken, Hans Kemperman, Mark Roest and Dylan W. de Lange

    Intensive Care Medicine Experimental 2017 5:7

    Published on: 25 January 2017

  20. Research

    Resuscitation fluid composition affects hepatic inflammation in a murine model of early sepsis

    Fluid resuscitation is a crucial therapy for sepsis, and the use of balanced fluids and/or isotonic albumin may improve patient survival. We have previously demonstrated that resuscitation with normal saline r...

    Amanda L. Patrick, Peter M. Grin, Nicole Kraus, Michelle Gold, Matthew Berardocco, Patricia C. Liaw and Alison E. Fox-Robichaud

    Intensive Care Medicine Experimental 2017 5:5

    Published on: 19 January 2017

  21. Research

    Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy

    Critically ill patients develop atrophic muscle failure, which increases morbidity and mortality. Interleukin-1β (IL-1β) is activated early in sepsis. Whether IL-1β acts directly on muscle cells and whether it...

    Nora Huang, Melanie Kny, Fabian Riediger, Katharina Busch, Sibylle Schmidt, Friedrich C. Luft, Hortense Slevogt and Jens Fielitz

    Intensive Care Medicine Experimental 2017 5:3

    Published on: 17 January 2017

  22. Letter to the Editor

    Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission

    Soluble TLR2 levels are elevated in infective and inflammatory conditions, but its diagnostic value with sepsis-induced multi-organ failure has not been evaluated. 37 patients with a diagnosis of severe sepsis...

    Benjamin Holst, Tamas Szakmany, Anne-Catherine Raby, Vincent Hamlyn, Kimberley Durno, Judith E. Hall and Mario O. Labéta

    Intensive Care Medicine Experimental 2017 5:2

    Published on: 13 January 2017

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