Table 1 Systemic hemodynamics, gas exchange, and metabolism

Body temperature (°C)

DMSO

36.5 (35.7, 37.4)

37.6 (37.0, 38.4)^a

38.4 (37.5, 38.7)^a

GW0742

36.9 (36.5, 37.3)

38.1 (37.7, 38.2)^a

38.0 (37.7, 38.3)^a

Heart rate (min^-1)

DMSO

83 (70, 99)

144 (121, 149)^a

149 (142, 163)^a

GW0742

69 (63, 92)

134 (126, 146)^a

158 (150, 162)^a

Mean arterial pressure (mmHg)

DMSO

103 (92, 108)

90 (87, 101)^a

75 (65, 98)^a

GW0742

110 (106, 114)

97 (93, 100)^a

83 (75, 94)^a

Mean pulmonary artery pressure (mmHg)

DMSO

25 (22, 26)

38 (28, 42)^a

39 (35, 40)^a

GW0742

27 (24, 27)

35 (34, 38)^a

42 (38, 47)^a

Central venous pressure (mmHg)

DMSO

13 (9, 14)

15 (12, 17)^a

18 (17, 18)^a

GW0742

13 (11, 15)

15 (13, 17)^a

19 (17, 22)^a

Pulmonary artery occluded pressure (mmHg)

DMSO

13 (10, 14)

15 (14, 17)^a

17 (17, 19)^a

GW0742

15 (11, 17)

16 (14, 18)^a

17 (16, 20)^a

Cardiac output (L·min^-1)

DMSO

4.4 (3.8, 5.2)

6.4 (5.7, 7.9)^a

8.0 (5.7, 9.3)^a

GW0742

4.4 (3.7, 5.2)

7.1 (6.1, 8.5)^a

7.6 (7.1, 7.8)^a

Hemoglobin (g·L^-1)

DMSO

94 (80, 100)

111 (99, 123)^a

115 (110, 121)^a

GW0742

91 (80, 102)

104 (107, 119)^a

110 (107, 119)^a

Arterial PO₂ (mmHg)

DMSO

176 (161, 185)

151 (121, 161)

118 (91, 144)^a

GW0742

180 (171, 181)

163 (125, 172)

118 (110, 139)^a

PaO₂/FiO₂ ratio (mmHg)

DMSO

550 (502, 583)

459 (362, 503)^a

244 (109, 398)^a

GW0742

536 (487, 611)

470 (392, 574)^a

236 (205, 386)^a

Arterial PCO₂ (mmHg)

DMSO

36 (34, 38)

38 (37, 41)

37 (35, 40)

GW0742

35 (33, 37)

38 (38, 39)

36 (34, 38)

Arterial pH

DMSO

7.45 (7.44, 7.46)

7.45 (7.39, 7.46)

7.35 (7.22, 7.41)^a

GW0742

7.45 (7.43, 7.46)

7.45 (7.40, 7.47)

7.36 (7.29, 7.41)^a

Arterial base excess (mmol·L^-1)

DMSO

1.2 (-0.3, 1.7)

1.7 (-1.1, 4.3)

-4.3 (-11.7, -0.8)^a

GW0742

0.4 (-0.5, 0.6)

2.5 (0.5, 4.0)

-5.3 (-7.7, -1.6)^a

Arterial lactate (mmol·L^-1)

DMSO

0.8 (0.7, 1.4)

1.0 (0.8, 2.0)

4.1 (1.7, 8.3)^a

GW0742

1.1 (0.9, 1.3)

1.0 (.7, 1.4)

2.6 (2.4, 4.5)^a

O₂ uptake (mL·kg^-1·min^-1)

DMSO

2.5 (2.2, 2.9)

3.0 (2.7, 3.1)

4.1 (3.5, 4.3)^a

GW0742

2.6 (2.5, 2.9)

2.7 (2.3, 3.5)

3.8 (3.4, 4.6)^a

CO₂ production (mL·kg^-1·min^-1)

DMSO

2.4 (2.2, 2.7)

2.8 (2.5, 3.0)

3.2 (3.1, 3.6)^a

GW0742

2.3 (2.0, 2.6)

2.6 (2.4, 3.0)

3.2 (2.8, 3.6)^a

Blood glucose (mg·dL)

DMSO

118 (109, 127)

76 (64, 88)^a

94 (73, 120)

GW0742

117 (111, 122)

68 (58, 73)^a

75 (69, 83)^a

Glucose production (mg·kg^-1·min^-1]

DMSO

1.3 (1.3, 1.5)

2.1 (2.0, 2.5)

3.0 (2.4, 3.3)

GW0742

1.3 (1.2, 1.8)

2.3 (2.1, 2.8)

3.0 (2.8, 3.5)

Glucose oxidation (mg·kg^-1·min^-1)

DMSO

0.4 (0.3, 0.4)

1.3 (1.2, 1.4)

1.7 (1.6, 2.1)

GW0742

0.3 (0.3, 0.4)

1.4 (1.3, 1.6)

1.9 (1.6, 2.3)