Table 2 Parameters of glucose metabolism and mitochondrial respiratory activity
| Â | Hyperglycemia | Normoglycemia | ||
|---|---|---|---|---|
Vehicle | EMD008 | Vehicle | EMD008 | |
Arterial glucose (mg · dL-1) | 151 (146;202)# | 138 (128;142)#§ | 104 (94;120) | 99 (71;122) |
Arterial lactate (mmol · L-1) | 3.2 (2.6;3.5)# | 3.8 (3.0;4.8)# | 2.1 (1.9;2.5) | 1.8 (1.5;1.9) |
CO2 production (μL · min-1) | 27 (25;32) | 29 (27;31) | 27 (25;27) | 24 (22;27) |
Gluconeogenesis (mg · g-1 · h-1) | 0.31 (0.26;0.35)# | 0.38 (0.33;0.40)#§ | 0.40 (0.38;0.45) | 0.53 (0.49;0.53)** |
Glucose oxidation (% isotope infusion) | 63 (57;67) | 62 (59;64) | 62 (60;64) | 63 (59;66) |
JO2-OXPHOS (pmol · s-1) | 116 (97;122)# | 136 (134;160)#§ | 150 (136;177) | 185 (167–197)§ |
JO2-ETC (pmol · s-1) | 147 (130;159)# | 166 (154;194)#* | 183 (171;193) | 210 (203;238)§ |