Volume 2 Supplement 1
0032. Relationship between microcirculatory alterations and venous-to-arterial carbon dioxide differences in patients with septic shock
© Ospina-Tascón et al; licensee Springer. 2014
Published: 26 September 2014
Increased venous to arterial carbon dioxide difference (Pv-aCO2) have been attributed to low cardiac output states. However, mechanisms conducting to Pv-aCO2 increases during normal or even high cardiac output conditions as in septic shock are not fully understood. We hypothesized that Pv-aCO2 could reflect the adequacy of microvascular perfusion during resuscitated septic shock
To test the hypothesis that Pv-aCO2 could reflect the microvascular blood flow during the early phases of resuscitation in septic shock
We included 80 patients with a first episode of septic shock admitted to a mixed ICU in a University Hospital over a 12-month period. Time 0 (T0) was set at ICU admission when a pulmonary artery catheter was inserted. Arterial and venous gases analyses were performed at T0 and 6 hours after (T6). We defined Pv-aCO2 as the difference between the mixed venous and arterial CO2 partial pressures. A Sidestream Dark-Field (SDF) imaging device (Microvision Medical, Amsterdam, the Netherlands) was used to evaluate the sublingual microcirculation both at T0 and T6. At each assessment, 5 sequences of 20 seconds each were recorded and stored under a random number. An investigator blinded to the sequence order and patient's clinical course, analyzed the sequences semi-quantitatively. The vessels were separated into large and small using a cut-off value of 20 µm in diameter. We evaluated the relation between the percentage of small vessels perfused and the Pv-aCO2 using linear and non-linear regressions and Spearman Rho test. A p< 0.05 was considered as significant.
General hemodynamics and Oxygen-derived parameters
Cardiac Index, (L/min/m2)
Microvascular blood flow is a key determinant of Pv-aCO2 during normodynamic septic shock. Pv-aCO2 could track microvascular alterations during early phases of septic shock.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.