Figure 2From: Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines Serial mean changes for HS animals vs. controls. This figure compares the serial mean (±SEM) changes from baseline in fluid in (A), fluid out (B), net fluid (C), pulmonary capillary wedge pressure (PCWP) (D), mean arterial blood pressure (E; MAP), heart rate (F; HR), lactate (G), blood urea nitrogen (H; BUN), creatinine (I), chloride (J), pH (K), and alveolar to arterial oxygen gradient (L; AaO2) for animals challenged with edema toxin and receiving no treatment (maintenance fluid only) versus hemodynamic support alone (HS; fluids and norepinephrine titrated to pulmonary artery wedge pressure and mean arterial blood pressure, respectively) in Study 1. Units of measure are shown in each panel. *p ≤ 0.05, **p < 0.0001.Back to article page