Figure 1From: Why do they die? Comparison of selected aspects of organ injury and dysfunction in mice surviving and dying in acute abdominal sepsis Survival curve and outcome prediction based on body temperature. (A) Seven-day mortality in 4-week-old OF-1 mice subjected to CLP-Only and daily low-volume blood sampling for days 1 to 5 post-CLP. (B) Experimental setup for prospective BT-based outcome prediction. A septic mouse was predicted to die (P-DIE) whenever its BT dropped below 28°C within days 1 to 5 post-CLP. Upon detection, each P-DIE mouse was always sacrificed with a matching predicted to survive (P-SUR) mouse (i.e. with BT ≥35°C). (C) ROC curve and corresponding area under the curve (AUC) for the prediction of outcome based on BT in acute CLP sepsis (days 1 to 5 post-CLP). BT ≤28°C identified dying mice with 94% specificity, while a BT ≥35°C identified surviving mice with 100% specificity. The BT cutoffs for outcome prediction utilized in this study were predetermined based on the internal BT measurement database compiled in previous studies.Back to article page