Parameter
|
AUC
|
Cutoff
|
Specificity (%)
|
Sensitivity (%)
|
---|
Urea | 0.85 | 77Â mg/dl | 100 | 40 |
Glucose | 0.78 | 30 U/l | 100 | 25 |
LDH | 0.68 | 1,320 U/l | 100 | 17 |
ALT | 0.68 | 365 U/l | 100 | 7 |
- CLP-Only mice were never sacrificed but sampled daily for blood between days 1 to 5 post-CLP and followed for 28 days. For ROC analysis, parameter values recorded within 24 h of death (occurring anytime between days 1 and 5 post-CLP) and from mice that lived until day 28 post-CLP were used. Specificity was set to 100% to identify only mice predicted to die without committing the type I error (i.e. an erroneous inclusion of P-SUR animals). ROC calculation was based on: n = 42 for mice that died within days 1 to 5 and n = 40 for mice that survived until day 28 post-CLP.