Gentisic acid sodium salt, a phenolic compound, is superior to norepinephrine in reversing cardiovascular collapse, hepatic mitochondrial dysfunction and lactic acidemia in Pseudomonas aeruginosa septic shock in dogs

Intensive Care Medicine Experimental

Table 1 Systemic vascular resistances in the five groups (dynes S/cm⁵: mean ± SD)

	Baseline	Septic/sham shock/condition	3 h post	5 h post
Non-septic control group (n = 16)	2299 ± 603	2794 ± 1024+	2819 ± 1114	2829 ± 1007
Septic control group (n = 13)	2583 ± 803	1351 ± 374*	1745 ± 1037	2226 ± 1503
Gentisic septic group (n = 11)	2717 ± 605	1272 ± 695*	2767 ± 607	3234 ± 1013#
Norepinephrine septic group (n = 10)	2778 ± 526	1539 ± .375*	2573 ± 968	2767 ± 1063
Gentisic non-septic group (n = 5)	2740 ± 340	2416 ± 499	1798 ± 256	1866 ± 25

Statistics by two way analysis of variance (ANOVA) and Student Newman Keuls multiple comparison test that included the five groups and four time periods. *P < 0.05 vs baseline; +P < 0.05 vs all septic groups; #P < 0.05 vs gentisic non septic group