Gentisic acid sodium salt, a phenolic compound, is superior to norepinephrine in reversing cardiovascular collapse, hepatic mitochondrial dysfunction and lactic acidemia in Pseudomonas aeruginosa septic shock in dogs

Intensive Care Medicine Experimental

Table 2 Cardiac indices in the five groups (l/min/kg: mean ± SD)

	Baseline	Septic/sham shock/condition	3 h post	5 h post
Non-septic control group (n = 16)	0.15 ± .03	0.15 ± .05	0.14 ± .04	0.13 ± .03
Septic control group (n = 13)	0.13 ± .04	0.17 ± .04	0.15 ± .07	0.11 ± .06
Gentisic septic group (n = 11)	0.12 ± .02	0.20 ± .08*+	0.12 ± .03	0.11 ± .04
Norepinephrine septic group (n = 10)	0.12 ± .02	0.15 ± .03	0.14 ± .03	0.14 ± .04
Gentisic non-septic group (n = 5)	0.12 ± .02	0.13 ± .02	0.16 ± .04	0.16 ± .05

Statistics by two way analysis of variance (ANOVA) and Student Newman Keuls multiple comparison test that included the five groups and four time periods. *P < 0.05 vs baseline; +P < 0.05 vs non septic control group