Gentisic acid sodium salt, a phenolic compound, is superior to norepinephrine in reversing cardiovascular collapse, hepatic mitochondrial dysfunction and lactic acidemia in Pseudomonas aeruginosa septic shock in dogs

Intensive Care Medicine Experimental

Table 3 Left ventricular filling pressures (Pwp) in the five groups (mmHg: mean ± SD)

	Baseline	Septic/sham shock/condition	3 h post	5 h post
Non-septic control group (n = 16)	10.8 ± .1.6	12.8 ± 1.8*%	13.8 ± 2.1*%	13.9 ± 1.8!
Septic control group (n = 13)	10.7 ± 1.1	8.8 ± 1.6*	9.4 ± 1.4#	9.3 ± .1.4#
Gentisic septic group (n = 11)	10.2 ± 1.6	9.3 ± 2.6	11 ± 2.6	12 ± .2.9*
Norepinephrine septic group (n = 10)	10.0 ± .2	9.0 ± 1.6	10.2 ± 2.8	10.1 ± 2.7#
Gentisic non-septic group (n = 5)	13.0 ± 2.6+	14.2 ± 3.7 %	14.2 ± 2.2 %	13.6 ± 4.2 %*

Statistics by two way analysis of variance (ANOVA) and Student Newman Keuls multiple comparison test that included the five groups and four time periods. *P < 0.05 vs baseline; %P < 0.05 vs all septic groups; #P < 0.05 vs gentisic septic group; !P < 0.05 vs septic control group and NE (norepinephrine) septic group; +P < 0.05 vs other groups