Fig. 141 (abstract A386).

Plasma concentrations of (A) tumor necrosis factor (TNF)ɑ, (B) interleukin (IL)-6, (C) IL-8, (D) IL-10 and (E) IL-1 receptor antagonist (IL-1RA) during endotoxin-elicited systemic infalmmation. Data are expressed as means with SEM. Effects of study treatment on the cytokine response were evaluated by comparing 2 groups with a 2-ways ANOVA. Significant differences between groups are displayed in the figure with a p-value. P: placebo, PA: placebo and acetylsalicylic acid, TA: ticagrelor and acetylsalicylic acid, CA: clopidogrel and acetylsalicylic acid