Fig. 60 (abstract A144).

General overview of the relationship between the in vivo and ex vivo models of sepsis described in the text. Rats are instrumented and following surgical recovery are administered with an intraperitoneal injection of either faecal slurry or normal saline. At 24 hours the animals are culled and blood removed. The blood is processed into serum and used for further experiments using slices of kidney tissue from a naïve rate. Serum and kidney slices incubated together may be examined for dynamic changes in mitochondrial function using fluorescent probes under a two-photon laser microscope