Lean critically ill (N = 24) | Overweight/obese critically ill (N = 24) | p valued | Healthy reference (N = 20) | p valuee | |
---|---|---|---|---|---|
Baseline characteristics | |||||
Gender (n, % male) | 17 (71) | 14 (58) | 0.5 | 14 (70) | 0.7 |
Age, years (mean ± SEM) | 68.4 ± 2.8 | 68.8 ± 2.8 | 0.5 | 70 ± 2.6 | 0.6 |
BMI, kg/m2 (mean ± SEM) | 22.5 ± 0.4 | 27.7 ± 0.3 | <0.0001 | 24.9 ± 2.6 | 0.8 |
Diabetes mellitus (n, %) | 4 (17) | 3 (12) | 1 | 3 (15) | 1 |
Malignancy (n, %) | 9 (37) | 9 (37) | 0.2 | ||
APACHE II score (mean ± SEM) | 25 ± 2 | 26 ± 2 | 0.5 | ||
Diagnostic admission category (n) | 0.3 | ||||
Cardiac surgery | 1 | 1 | |||
Complicated surgerya | 1 | 5 | |||
Multiple trauma or burns | 0 | 1 | |||
Hematologic or oncologic | 4 | 5 | |||
Respiratory | 12 | 7 | |||
Other disease exacerbationsb | 4 | 4 | |||
Other sepsis | 2 | 1 | |||
Randomization to intensive insulin therapy (n, %) | 10 (42) | 11 (46) | 1 | ||
Received steroid therapy (n, %) | 17 (73) | 18 (85) | 0.4 | ||
Outcome | |||||
ICU stay (median (IQR))c | 10 (7-20) | 10 (6-17) | 0.2 | ||
Cause of death (n) | 0.5 | ||||
Cardiac/hypovolemic shock | 4 | 4 | |||
Multiple organ failure | 8 | 12 | |||
Respiratory failure | 8 | 7 | |||
Septic shock/therapy resistance | 3 | 1 | |||
Severe brain damage | 1 | 0 |