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Intensive Care Medicine Experimental
Fig. 2 | Intensive Care Medicine Experimental

Fig. 2

From: Impact of downstream effects of glucocorticoid receptor dysfunction on organ function in critical illness-associated systemic inflammation

Fig. 2

After binding of the glucocorticoids (GCs are shown as small ellipses) as ligands to the glucocorticoid receptor GR, the immunophillins (Fkbp51, Fkbp52), heat shock proteins (Hsp70, Hsp90, p23), and chaperonic molecules dissociate and the GR translocates in the nucleus. In the nucleus, the ligand-bound GR can either act as a monomer or a homodimer

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