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Intensive Care Medicine Experimental
Fig. 3 | Intensive Care Medicine Experimental

Fig. 3

From: Impact of downstream effects of glucocorticoid receptor dysfunction on organ function in critical illness-associated systemic inflammation

Fig. 3

The classical dogma that the glucocorticoid receptor (GR) monomer by interaction with pro-inflammatory transcription factors with AP-1, NF-κB, or half glucocorticoid response elements (1/2 GRE) mediate beneficial effects while the dimer mediates side effects by direct binding to GREs does not hold true. The GR dimer is also important to mediate beneficial effects and the monomer side effects

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