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Intensive Care Medicine Experimental
Fig. 2 | Intensive Care Medicine Experimental

Fig. 2

From: In an endotoxaemic model, antibiotic clearance can be affected by different central venous catheter positions, during renal replacement therapy

Fig. 2

Flowchart of the method. Eighteen [18] piglets were randomized in pairs (2 × n = 9) to start continuous renal replacement therapy (CRRT) in either the external jugular vein (EJV) or the femoral vein (FV). Lipopolysaccharide (LPS) was given in a peripheral vein throughout the whole experiment in order to induce endotoxaemia. An infusion of antibiotic (AB) (Gentamicin 4.55 mg/ml and vancomycin 10 mg/ml) were started before CRRT in the EJV and kept throughout the whole experiment. An infusion of noradrenaline (NA) 20 µg/ml was started in the EJV if the mean arterial pressure (MAP) was below 60 mmHg. During the 30-min experiment period, target MAP was 75 mmHg. After 30 min, the CRRT was shifted to the other CVDC and the experiment was repeated. Black arrows indicate sampling times for dialysate and serum laboratory tests and time for registering the noradrenaline dose. In one experiment period, infusion of antibiotics and noradrenaline was close to the central venous dialysis catheter and the CRRT (i.e. in the EJV) and in the other experiment period they were in different vessels (i.e. in the FV). The animals served as their own controls

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