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Intensive Care Medicine Experimental
Fig. 1 | Intensive Care Medicine Experimental

Fig. 1

From: Colonic oxygen microbubbles augment systemic oxygenation and CO2 removal in a porcine smoke inhalation model of severe hypoxia

Fig. 1

Porcine smoke inhalation injury. A, B Before and after (D, E) chest X-ray images confirming the presence of diffuse bilateral infiltrates indicative of ARDS due to smoke inhalation injury. C PaO2 (red, p = 0.000147), PmvO2 (blue, p < 0.0001), SpO2 (violet, p < 0.0001), PaCO2 (gold, p < 0.0001), PmvCO2 (green, p = 0.000123) and ETCO2 (teal, p < 0.0001) measurements taken both before (t = − 48 h) and after (t = − 0.5 h) smoke inhalation injury. Hematoxylin and eosin (H&E) staining of paraffin-embedded lung tissue sections of baseline (t = − 48 h) (F) and SI + 48 h (t = − 0.5 h) (G) animals (scale bar = 100 µm). H IL-6 marker analysis for baseline and smoke injury (SI) + 2 h (t = − 46 h) for BAL and plasma samples. Comparison of lung injury score (I) and lung wet/dry ratios (J) showing a significant difference between control and SI + 48 h (t = − 0.5 h) samples (p < 0.0001 and p = 0.0188, respectively)

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