Intensive Care Medicine Experimental

Table 2 Colonic OMB mixed effects analysis

From: Colonic oxygen microbubbles augment systemic oxygenation and CO₂ removal in a porcine smoke inhalation model of severe hypoxia

P_aO₂					P_mvO₂					SpO₂
Fixed effects (type III)					Fixed effects (type III)					Fixed effects (type III)
	DFn	DFd	F	P value		DFn	DFd	F	P value		DFn	DFd	F	P value
Time	3.21	30.5	0.5267	0.6791	Time	2.771	26.33	1.066	0.3764	Time	2.731	25.94	0.7014	0.5471
Treatment	1	10	26.58	0.0004	Treatment	1	10	8.313	0.0163	Treatment	1	10	7.593	0.0182
Time × treatment	6	57	2.418	0.0376	Time × treatment	6	57	2.101	0.0672	Time × treatment	6	57	2.983	0.0133
Random effects	SD	Variance			Random effects	SD	Variance			Random effects	SD	Variance
Subject	5.027	25.27			Subject	5.231	27.36			Subject	12.3	151.3
Residual	4.63	21.44			Residual	3.761	14.14			Residual	6.417	41.17

P_aCO₂					P_mvCO₂					ETCO₂
Fixed effects (type III)					Fixed effects (type III)					Fixed effects (type III)
	DFn	DFd	F	P value		DFn	DFd	F	P value		DFn	DFd	F	P value
Time	2.254	18.41	0.1742	0.8647	Time	2.372	20.16	1.935	0.165	Time	2.078	19.75	0.8246	0.4571
Treatment	1	9	56.57	< 0.0001	Treatment	1	9	25.99	0.0006	Treatment	1	10	33.81	0.0002
Time × treatment	6	49	7.718	< 0.0001	Time × treatment	6	51	7.867	< 0.0001	Time × treatment	6	57	5.926	< 0.0001
Random effects	SD	Variance			Random effects	SD	Variance			Random effects	SD	Variance
Subject	4.926	24.26			Subject	4.428	19.6			Subject	3.959	15.67
Residual	4.074	16.6			Residual	3.836	14.71			Residual	4.065	16.52

The mixed effects analysis for the colonic OMB treatment and no-treatment groups delta in measurement from baseline as plotted in Fig. 6C–H. The model assumes an alpha of 0.05 with no sphericity

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