The impact of intravenous dodecafluoropentane on a murine model of acute lung injury

Intensive Care Medicine Experimental

Table 1 Linear hypothesis tests of differences between DDFPe and saline treated mice (n = 6/group) at each time point using Kenward–Roger adjustments to the denominator degrees of freedom and standard errors

Time point	Estimate difference	t statistic	df	p value	95% CI
Baseline**	− 3.63	− 1.75	22.18	0.09	− 7.93, 0.67
15 min	− 2.56	− 1.29	18.72	0.21	− 6.71–1.60
30 min	− 1.48	− 0.77	15.96	0.44	− 5.52–2.56
45 min	− 0.40	− 0.21	13.81	0.82	− 4.34–3.54
60 min	0.67	0.37	12.21	0.71	− 3.20–4.54
75 min	1.75	1.00	11.07	0.33	− 2.07–5.57
90 min	2.82	1.65	10.35	0.12	− 0.9–6.62
105 min	3.90	2.30	10.02	0.04	0.13–7.67
120 min**	4.98	2.94	10.07	0.01	1.21–8.76
135 min	6.05	3.54	10.48	0.005	2.26–9.85
150 min	7.14	4.09	11.29	0.002	3.31–10.97
165 min	8.21	4.58	12.52	< 0.001	4.33–12.10
180 min	9.29	5.01	14.24	< 0.001	5.33–13.25
195 min	10.37	5.39	16.52	< 0.001	6.30–14.43
210 min	11.44	5.71	19.42	< 0.001	7.25–15.63
225 min	12.52	5.98	23.04	< 0.001	8.19–16.85