Table 2 Ventilation parameters
| Â | INTELLiVENT-ASV | Conventional ventilation | P value |
|---|---|---|---|
Primary endpoint | |||
 ∆PTP (cmH2O) | 7.0 (5.0–10.0) | 10.0 (8.0–11.0) | 0.0002 |
Secondary endpoint | |||
 ∆PRS (cmH2O) | 12.8 (12.0–15.0) | 13.2 (12.0–15.0) | 0.35 |
 Pplat (cmH2O) | 24.0 (24.0–25.0) | 25.0 (24.0–26.0) | 0.055 |
 PEEP (cmH2O) | 12.0 (10.0–12.0) | 12.0 (9.0–12.0) | 0.55 |
 PTP inspiratory | 18.0 (17.0–20.0) | 20.0 (19.0–23.0) | 0.0002 |
 VT (mL) | 498 (462–517) | 453 (419–490) | 0.003 |
 VT (mL/kg PBW) | 6.9 (6.4–7.2) | 6.3 (5.8–6.8) | 0.002 |
 RR (breaths/min) | 20 (18–21) | 23 (21–23) | < 0.001 |
 Min. Vol (L/min) | 9.8 (8.9–10.5) | 10.1 (9.2–11.1) | 0.03 |
 CRS (mL/cmH2O) | 34.0 (31.0–41.0) | 34.0 (30.0–39.0) | 0.11 |
 CL (mL/cmH2O) | 26.1 (23.5–29.7) | 21.8 (19.6–24.3) | 0.00027 |
 CCW (mL/cmH2O) | 83.5 (67.8–96.1) | 124.5 (99.6–186.5) | 0.0003 |
 EL (cmH2O/L) | 15.2 (11.3–19.1) | 22.5 (16.7–26.5) | < 0.001 |
 MPTP (J/min) | 14.1 (12.7–15.6) | 15.7 (14.2–17.4) | 0.0006 |
 MPRS (J/min) | 17.1 (15.7–18.9) | 17.7 (15.6–19.4) | 0.51 |
 FiO2 (%) | 0.63 (0.50–0.70) | 0.60 (0.50–0.67) | 0.06 |
 SpO2 (%) | 94 (93–96) | 96 (93–96) | 0.07 |
 etCO2 (kPa) | 6.3 (5.3–6.7) | 6.1 (5.8–6.7) | 0.001 |
 VR | 1.9 (1.7–2.5) | 2.3 (2.0–2.7) | 0.095 |
Blood gas variables | |||
 pH | 7.31 (7.28–7.34) | 7.32 (7.29–7.34) | 0.79 |
 pCO2 (kPa) | 7.9 (6.7–8.4) | 7.7 (7.1–8.0) | 0.53 |
 pO2 (kPa) | 8.7 (7.9–9.6) | 8.9 (8.1–9.9) | 0.62 |
 Bic (mmol/L) | 20.0 (18.0–22.0) | 21.0 (18.0–22.0) | 0.43 |
 Arterial sat. (%) | 94 (93–96) | 96 (93–96) | 0.17 |