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Intensive Care Medicine Experimental

Table 1 Demographic characteristics of the study population stratified according to neurological outcome and temperature treatment

From: Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest

Characteristica

Good outcome

(N = 31)

Poor outcome

(N = 47)

33 °C group (N = 41)

36 °C group

(N = 37)

Demographic characteristics

 Age in years

62 ± 11

69 ± 12

64 ± 13

68 ± 11

 Male sex

27 (87)

35 (75)

36 (88)

26 (70)

Medical history

 Chronic heart failure

1/28 (4)

4/44 (9)

1/39 (3)

4/33 (12)

 Previous acute myocardial infarction

5/28 (18)

9/44 (21)

8/39 (21)

6/33 (18)

 Ischaemic heart disease

5/28 (18)

12/44 (27)

9/39 (23)

8/33 (24)

 Previous cardiac arrhythmia

5/28 (18)

12/44 (27)

8/39 (21)

9/33 (27)

 Arterial hypertension

13/28 (46)

21/44 (48)

19/39 (49)

15/33 (46)

 Previous TIA or stroke

1/28 (4)

9/44 (21)

4/39 (10)

6/33 (18)

 Diabetes mellitus

1/28 (4)

9/44 (21)

3/39 (8)

7/33 (21)

 Asthma or COPD

4/28 (14)

7/44 (16)

2/39 (5)

9/33 (27)

 Previous percutaneous coronary intervention

2/28 (7)

5/44 (11)

4/39 (10)

3/33 (9)

 Previous coronary-artery bypass grafting

0/28 (0)

5/44 (11)

5/39 (13)

0/33 (0)

Characteristics of the cardiac arrest

 Bystander witnessed cardiac arrest

28 (90)

45 (96)

37 (90)

36 (97)

 Shockable rhythm

27 (87)

23 (49)

28 (68)

22 (59)

 Minutes from cardiac arrest to ROSC

23 (15–33)

35 (23–50)

30 (20–43)

30 (19–48)

Clinical characteristics on admission

 First measured body temperature in °Cd

35.9 ± 0.8

35.9 ± 0.9

35.7 ± 0.9

36.0 ± 0.8

 Glasgow Coma Scale scoreb,d

5 (4–6)

3 (3–3)

3 (3–5)

3 (3–5)

 Corneal reflex bilaterally present

16/26 (62)

8/44 (18)

14/38 (37)

10/32 (31)

 Pupillary reflex bilaterally present

27/30 (90)

19/47 (40)

24/40 (60)

22/37 (60)

 Serum pHd

7.3 ± 0.1

7.1 ± 0.2

7.2 ± 0.1

7.1 ± 0.2

 Serum lactate in mmol/literd

6.2 ± 3.7

9.2 ± 4.2

7.5 ± 4.1

8.7 ± 4.5

 Circulatory shockc

2/28 (7)

7/44 (16)

4/39 (10)

5/33 (15)

 ST-segment elevation in acute myocardial infarction

11/28 (39)

12/44 (27)

12/39 (31)

11/33 (33)

Allocation to 33 °C

20 (65)

21 (45)

41 (100)

0 (0)

Poor outcome (CPC 3–5) at 6 months

0 (0)

47 (100)

21 (51)

26 (70)

  1. aResults are reported as numbers [/total number] (percentages), median (interquartile range), or mean (± standard deviation) as appropriate. COPD chronic obstructive pulmonary disease; TIA transient ischaemic attack; ROSC return of spontaneous circulation
  2. bScores on the Glasgow Coma Scale range from 3 to 15, with lower scores indicating reduced level of consciousness
  3. cCirculatory shock was defined as a systolic blood pressure of less than 90 mm Hg for more than 30 min or end-organ hypoperfusion (cool extremities, urine output < 30 ml per hour, and a heart rate of < 60 beats per minute)
  4. dMissing values. ‘First measured body temperature’ was missing data for 2 patients and ‘Glasgow Coma Scale score’ was missing data for 8 patients; ‘Serum pH’ and ‘Serum lactate’ were missing data for 6 patients
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