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Intensive Care Medicine Experimental
Fig. 3 | Intensive Care Medicine Experimental

Fig. 3

From: Splanchnic sympathetic nerve denervation improves bacterial clearance and clinical recovery in established ovine Gram-negative bacteremia

Fig. 3

Changes in plasma inflammatory and anti-inflammatory cytokines in response to bilateral splanchnic denervation or sham procedure during ovine Gram-negative bacteremia. Plasma IL-6 (A), IFN-γ (B), IL-8 (C), IL-10 (D) and TNF-α (E) during infusion of E. coli from 0 to 30-h of bacteremia. Animals were randomized to either splanchnic-denervated (n = 9) or untreated (sham, n = 9) at 24-h of bacteremia. Baseline, 23-h, 25-h, 27-h and 30-h are the sampled timepoints. Data are presented as treatment group-specific mean ± SEM. P values represent the results of a 2-way ANOVA assessing differences between the groups (splanchnic-denervated vs sham) and treatment time points (from 24 to 30-h of bacteremia) and the interaction between group and time. A two-sided P value < 0.05 was considered to be significant

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