Splanchnic sympathetic nerve denervation improves bacterial clearance and clinical recovery in established ovine Gram-negative bacteremia

Intensive Care Medicine Experimental

Table 1 Arterial blood gasses and lactate at 23-h of sepsis and following bilateral splanchnic nerve denervation or sham at 24-h of bacteremia in conscious sheep

	Baseline	23 h	Post-splanchnic/sham denervation
	Baseline	23 h	25 h	27 h	30 h
Arterial pO₂(mmHg)
SPX	104 ± 2	76 ± 7⁺⁺	81 ± 5	79 ± 5	81 ± 6⁺⁺
Sham	101 ± 3	79 ± 7^##	79 ± 8	80 ± 7	77 ± 7^##
Arterial pCO₂ (mmHg)
SPX	33 ± 1	29 ± 1	32 ± 1	32 ± 1	31 ± 1
Sham	32 ± 2	32 ± 2	32 ± 2	31 ± 2	32 ± 2
Arterial Hb (g/dL)
SPX	11.4 ± 0.4	10.0 ± 0.4⁺⁺⁺	9.4 ± 0.4	9.6 ± 0.3	9.2 ± 0.3⁺⁺⁺
Sham	10.4 ± 0.5	9.4 ± 0.3	9.2 ± 0.5	9.2 ± 0.3	9.1 ± 0.3
Arterial pH
SPX	7.51 ± 0.01	7.56 ± 0.01⁺⁺	7.55 ± 0.01	7.56 ± 0.02	7.56 ± 0.01⁺
Sham	7.50 ± 0.01	7.56 ± 0.01^###	7.57 ± 0.01	7.58 ± 0.01	7.57 ± 0.01^###
Arterial lactate (mmol/L)
SPX	0.52 ± 0.13	0.95 ± 0.09	0.87 ± 0.08	0.87 ± 0.15	0.78 ± 0.10
Sham	0.56 ± 0.09	1.17 ± 0.22	1.72 ± 0.78	1.03 ± 0.24	0.84 ± 0.15

SPX Splanchnic-denervated (n = 10), Sham Sham-denervated (n = 9). ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 represent significant differences between baseline and 23-h and 30-h of Gram-negative bacteremia using a two-tailed paired Student T-test in the sham group (A Bonferroni correction of K = 2 was applied to p values). ⁺P < 0.05, ⁺⁺P < 0.01, ⁺⁺⁺P < 0.001 represent significant differences between baseline and 23-h and 30-h of Gram-negative bacteremia using a two-tailed paired Student T-test in the splanchnic-denervated group (A Bonferroni correction of K = 2 was applied to p values)