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Intensive Care Medicine Experimental
Fig. 5 | Intensive Care Medicine Experimental

Fig. 5

From: Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions

Fig. 5

Timing of antibiotic administration shows effect on disease severity. Kaplan–Meier survival curves (A), temperature (B), MSS (C), and percent weight change (D) over time in FIP-treated and sham-treated mice. Animals received FIP with 0.75 mg/g; see series 2 (early) and series 3 (late) at site 1 for experimental details (Table 1). Data are presented as median ± interquartile range from sham-treated mice (n = 8; 4 male, 4 female), FIP-treated mice with early intervention (n = 10; 5 male, 5 female), and FIP-treated mice with late intervention (n = 20; 10 male, 10 female). Bacterial loads for PCF (E), and bacterial loads for blood (F) were recorded for each mouse. Data are presented as violin plots. Confluent bacterial loads were omitted as the colonies were uncountable

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