Table 1 An outline of our experimental design

1

1

2021

0.5, 0.75, 1, 1.5, 2.5

Buprenorphine (0.01 mg/kg)

(4 h, 16 h, q8h onwards)

Ringer’s (200 µL, 4 h)

Ringer’s (100 µL. 16 h, q8h onwards)

Piptazo (25 mg/kg) (8 h, q8h onwards)

2

1

2021

0.75

Buprenorphine (0.05 mg/kg)

(4 h, 12 h, q12h onwards)

Ringer’s (20 mL/kg)

(4 h, 12 h)

Ringers (15 mL/kg)

(24 h, q12h onwards)

Imipenem (25 mg/kg) (4 h, 12 h, q12h onwards)

3

1

2021

0.75

Buprenorphine (0.05 mg/kg)

(4 h, 12 h, q12h onwards)

Ringer’s (15 mL/kg)

(12 h, q12h onwards}

Imipenem (25 mg/kg) (12 h, q12h onwards)

3

2

2021

0.5, 0.625, 0.75

Buprenorphine (0.05 mg/kg)

(4 h, 12 h, ql2h onwards)

Ringer’s (15 mL/kg)

(12 h, ql2h onwards)

Imipenem (25 mg/kg) (12 h, q12h onwards)

4

2

2020

0.75

Buprenorphine (0.05 mg/kg) (4 h, 12 h, ql2h onwards)

Ringer’s (15 mL/kg) (12 h, ql2h onwards)

Imipenem (25 mg/kg) (12 h, q12h onwards)