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Intensive Care Medicine Experimental

Table 4 Relationship between major amino-acid substitutions in spike receptor binding domain (RBD) and hospital mortality in univariable Cox proportional hazard regression analysis

From: Clinical phenotypes and outcomes associated with SARS-CoV-2 Omicron variants BA.2, BA.5 and BQ.1.1 in critically ill patients with COVID-19: a prospective, multicenter cohort study

Non synonymous mutations in Spike RBD

Na

HR 95% CI

P value

R346T/I

34

1.10 [0.47; 2.57]

0.821

K444T/R

29

1.29 [0.62; 3.38]

0.389

L452R

81

1.33 [0.49; 3.56]

0.575

N460K

28

1.49 [0.64; 3.48]

0.353

F486V

81

1.33 [0.49; 3.56]

0.575

  1. HR 95% CI: Hazard ratio 95% Confidence Interval; aNumber of patients with the mutation on a total of 108 patient-related samples for which full-length viral genome sequence analysis yielding high coverage with > 95% on spike gene was performed
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