Table 1 Association between cluster membership and cardiorespiratory parameters
Cluster 5 | Cluster 3 | Cluster 2 | Cluster 1 | Cluster 4 | P | |
|---|---|---|---|---|---|---|
Non-inverted ventilation-dependent | Intermediate | Inverted perfusion-dependent | ||||
Lung injury | ||||||
Lung injured/uninjured ratio (% injured) | 8/17 (32%) | 5/13 (28%) | 5/4 (56%) | 3/3 (50%) | 12/3 (80%) | 0.02 |
PaO2/FiO2 ratio (kPa) | 44 (11) | 43 (10) | 39 (9) | 39 (9) | 25 (11) | < 0.001 |
PaO2/FiO2 ratio (mmHg) | 332 (84) | 323 (74) | 291 (66) | 294 (70) | 188 (83) | < 0.001 |
Lung mechanics | ||||||
Tidal volume (mL) | 270 (114) | 333 (88) | 396 (117) | 397 (134) | 323 (107) | 0.02 |
PEEP (cmH2O) | 9 (3) | 8 (2) | 9 (3) | 11 (1) | 9 (3) | 0.08 |
Plateau pressure (cmH2O) | 19 (5) | 20 (5) | 26 (6) | 30 (3) | 22 (5) | < 0.001 |
Driving pressure (cmH2O) | 10 (4) | 12 (5) | 17 (6) | 18 (3) | 12 (4) | < 0.001 |
Dynamic compliance (mL/cmH2O) | 28 (8) | 28 (8) | 24 (9) | 22 (8) | 26 (5) | 0.55 |
Mechanical power (J/min) | 5.3 (3.8) | 6.5 (2.6) | 9.5 (3.3) | 12.4 (3.1) | 7.2 (3.9) | < 0.001 |
Haemodynamic variables | ||||||
Cardiac output (L/min) | 4.74 (1.13) | 4.20 (1.21) | 5.36 (0.93) | 5.39 (0.95) | 4.88 (0.88) | 0.05 |
Heart rate (/min) | 125 (27) | 110 (17) | 146 (26) | 125 (7) | 132 (27) | 0.01 |
Mean arterial pressure (mmHg) | 102 (19) | 98 (18) | 100 (12) | 92 (25) | 80 (10) | 0.004 |
Pulse pressure variation (%) | 12.3 (5.7) | 12.6 (5.3) | 12.7 (4.0) | 20.8 (4.2) | 20.0 (8.3) | < 0.001 |
Central venous pressure (mmHg) | 15 (2) | 14 (2) | 14 (1) | 13 (2) | 12 (2) | 0.002 |
Pulmonary artery pressure (mmHg) | 27 (5) | 26 (5) | 25 (4) | 24 (5) | 29 (5) | 0.24 |
Systemic vascular resistance (dynes.s/cm5) | 1546 (399) | 1724 (430) | 1348 (356) | 1246 (556) | 1161 (329) | 0.002 |