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Intensive Care Medicine Experimental

Table 3 Displays relevant demographics and outcome parameters dived into two groups above the calculated threshold (HsTnT > 1264 ng/L) by the means of Youden Index

From: Timing and threshold of high sensitive troponin T measurement for the prediction of mortality after cardiac surgery: a retrospective cohort analysis

 

hs Troponin T < 1264 ng/L at d2 after surgery

hs Troponin T > 1264 ng/L at d2 after surgery

n

1707

262

p

Height on admission (cm) (mean (SD))

170.38 (11.20)

170.02 (12.67)

0.630

Weight on admission (kg) (mean (SD))

81.05 (19.40)

81.15 (20.61)

0.941

Age on admission (mean (SD))

67.28 (10.71)

67.77 (10.95)

0.493

Sex = male (n (%))

438 (25.7)

76 (29.0)

0.283

Procedure

   

 Intervention CABG (n (%))

976 (57.2)

138 (52.7)

0.193

 Intervention AVR (n (%))

632 (37.0)

71 (27.1)

0.002

 Intervention Valve (non AVR) (n (%))

808 (47.3)

148 (56.5)

 < 0.001

Preexisting conditions

   

 Lung Disease (n (%))

170 (10.0)

21 (8.0)

0.380

 Diabetes (n (%))

363 (21.3)

52 (19.8)

0.658

 Art. hypertension (n (%))

1145 (67.1)

168 (64.1)

0.382

 Renal dysfunction (n (%))

254 (14.9)

70 (26.7)

 < 0.001

Premedication

   

 Betablocker (n (%))

912 (53.4)

140 (53.4)

1.000

 ACE inhibitor (n (%))

614 (36.0)

81 (30.9)

0.127

 Statin (n (%))

1042 (61.0)

137 (52.3)

0.009

Outcome

   

 Deceased (n (%))

23 (1.3)

38 (14.5)

 < 0.001

 First hs Troponin T d0 (ng/L) (median [IQR])

800.00 [505.50, 1,291.00]

3387.00 [2064.75, 5,190.25]

 < 0.001

 Second hs Troponin T d1 (ng/L) (median [IQR])

529.00 [326.00, 841.00]

2989.00 [2056.25, 4,729.75]

 < 0.001

 Third hs Troponin T d2 (ng/L) (median [IQR])

346.00 [218.00, 554.00]

2006.50 [1539.75, 3,538.25]

 < 0.001

 Fourth hs Troponin T d3 (ng/L) (median [IQR])

323.00 [199.00, 522.25]

1779.50 [1284.00, 2,826.00]

 < 0.001

AKI KDIGO within first 48 h (n (%))

  

 < 0.001

 KDIGO 0

24 (1.4)

1 (0.4)

 

 KDIGO 1

251 (14.7)

24 (9.2)

 

 KDIGO 2

1385 (81.1)

183 (69.8)

 

 KDIGO 3

47 (2.8)

54 (20.6)

 

 Norepinephrine max. dose (µg/kg/min) (mean (SD))

0.14 (0.12)

0.24 (0.21)

 < 0.001

 Days of Stay at ICU (mean (SD))

4.96 (6.03)

10.68 (10.97)

 < 0.001

 Lactate avg. at d0 (mmol/L) (mean (SD))

1.61 (0.58)

2.26 (1.43)

 < 0.001

 Lactate avg. at d1 (mmol/L) (mean (SD))

1.38 (0.45)

1.95 (1.26)

 < 0.001

 SAPS3 (mean (SD))

42.39 (9.84)

48.24 (13.21)

 < 0.001

 Cross Clamp Time (min) (mean (SD))

69.12 (35.53)

100.67 (54.92)

 < 0.001

 CPB Time (min) (mean (SD))

113.86 (52.94)

171.07 (83.36)

 < 0.001

  1. Values are presented in mean (SD) or median [IQR] as appropriate due to distribution. Dichotomous variables are counted in n (%)
  2. AVR aortic valve replacement, CABP coronary artery bypass grafting, AKI acute kidney Injury, KDIGO Kidney Disease: Improving Global Outcomes classes 1–4, CPB Cardio Pulmonary Bypass)
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