Fluid restrictive resuscitation with high molecular weight hyaluronan infusion in early peritonitis sepsis

Tenhunen, Annelie Barrueta; van der Heijden, Jaap; Skorup, Paul; Maccarana, Marco; Larsson, Anders; Larsson, Anders; Perchiazzi, Gaetano; Tenhunen, Jyrki

doi:10.1186/s40635-023-00548-w

Intensive Care Medicine Experimental

Table 1 Hemodynamics

From: Fluid restrictive resuscitation with high molecular weight hyaluronan infusion in early peritonitis sepsis

	Group	Baseline (n = 8 + 8)	1 h of peritonitis (n = 8 + 8)	2 h of peritonitis (n = 8 + 8)	3 h of peritonitis (n = 8 + 8)	6 h of peritonitis (n = 8 + 8)	p value
BE (mEq/l)	HA	2.0 ± 3.9	2.1 ± 2.3	1.5 ± 1.7	0.5 ± 1.5	− 4.1 ± 3.3	0.061
BE (mEq/l)	Control	4.6 ± 1.5	1.8 ± 2.0	1.7 ± 1.9	1.4 ± 2.0	− 1.2 ± 3.9	0.061
CI (l/min/kg)	HA	0.09 ± 0.02	0.11 ± 0.01	0.10 ± 0.01	0.10 ± 0.01	0.07 ± 0.02	0.051
CI (l/min/kg)	Control	0.09 ± 0.02	0.09 ± 0.01	0.09 ± 0.01	0.09 ± 0.01	0.08 ± 0.01	0.051
CVP (mmHg)	HA	9 ± 2	8 ± 3	8 ± 3	7 ± 3	7 ± 2	0.049^*
CVP (mmHg)	Control	9 ± 3	9 ± 3	9 ± 3	8 ± 3	7 ± 3	0.049^*
ERO2	HA	0.55 ± 0.13	0.49 ± 0.09	0.50 ± 0.08	0.51 ± 0.10	0.66 ± 0.14	0.050^*
ERO2	Control	0.48 ± 0.05	0.53 ± 0.11	0.53 ± 0.09	0.47 ± 0.09	0.60 ± 0.05	0.050^*
Hb (g/l)	HA	89 ± 10	99 ± 8	110 ± 9	120 ± 10	127 ± 8	0.219
Hb (g/l)	Control	93 ± 6	100 ± 10	106 ± 13	114 ± 13	129 ± 13	0.219
HR (BPM)	HA	94 ± 9	102 ± 21	129 ± 41	159 ± 51	178 ± 41	0.008^*
HR (BPM)	Control	94 ± 19	86 ± 14	96 ± 23	108 ± 26	170 ± 44	0.008^*
pH	HA	7.40 ± 0.06	7.37 ± 0.04	7.35 ± 0.02	7.35 ± 0.04	7.31 ± 0.05	0.844
pH	Control	7.43 ± 0.02	7.37 ± 0.02	7.38 ± 0.02	7.36 ± 0.03	7.33 ± 0.07	0.844
SV (ml)	HA	29 ± 6	33 ± 7	26 ± 8	21 ± 7	13 ± 4	0.347
SV (ml)	Control	28 ± 7	32 ± 3	29 ± 5	26 ± 4	14 ± 4	0.347
SVI (ml/kg)	HA	1.0 ± 0.2	1.1 ± 0.2	0.9 ± 0.3	0.7 ± 0.2	0.4 ± 0.1	0.350
SVI (ml/kg)	Control	0.9 ± 0.2	1.1 ± 0.1	1.0 ± 0.1	0.9 ± 0.1	0.5 ± 0.1	0.350
SvO2 (%)	HA	43 ± 13	48 ± 9	48 ± 8	46 ± 10	31 ± 13	0.060
SvO2 (%)	Control	50 ± 4	45 ± 11	45 ± 9	51 ± 8	37 ± 4	0.060
T (° C)	HA	40.2 ± 0.8	40.2 ± 0.8	40.6 ± 1.0	41.1 ± 1.1	41.3 ± 1.3	0.190
T (° C)	Control	39.7 ± 0.5	39.9 ± 0.8	40.2 ± 0.9	40.7 ± 1.0	41.6 ± 0.8	0.190
Wedge Pressure (mmHg)	HA	12 ± 2	10 ± 3	10 ± 2	10 ± 2	12 ± 7	0.827
Wedge Pressure (mmHg)	Control	11 ± 2	11 ± 3	11 ± 3	10 ± 3	11 ± 3	0.827

BE base excess, CI Cardiac index, CVP central venous pressure, ERO₂ Oxygen extraction ratio, Hb hemoglobin, HR heart rate, SV stroke volume, SVI stroke volume index, SvO₂ mixed venous saturation, T temperature. Values expressed as mean ± SD. Groups compared throughout the experiment with the mixed model analysis, p value of 0.05 was considered to be statistically significant, marked * in table

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