Fluid restrictive resuscitation with high molecular weight hyaluronan infusion in early peritonitis sepsis

Intensive Care Medicine Experimental

Table 2 Respiratory parameters

	Group	Baseline (n = 8 + 8)	1 h of peritonitis (n = 8 + 8)	2 h of peritonitis (n = 8 + 8)	3 h of peritonitis (n = 8 + 8)	6 h of peritonitis (n = 8 + 8)	p value
Cstat (ml/cmH2O)	HA	27 ± 4	28 ± 6	25 ± 4	24 ± 4	23 ± 3	0.410
Cstat (ml/cmH2O)	Control	26 ± 4	24 ± 3	23 ± 3	22 ± 2	21 ± 3	0.410
EVLW (ml)	HA	295 ± 36	316 ± 33	308 ± 33	311 ± 43	320 ± 38	0.620
EVLW (ml)	Control	308 ± 63	320 ± 59	326 ± 66	325 ± 73	358 ± 118	0.620
MPAP (mmHg)	HA	20 ± 2	22 ± 4	23 ± 1	22 ± 2	25 ± 3	0.267
MPAP (mmHg)	Control	20 ± 4	18 ± 3	22 ± 3	21 ± 4	25 ± 4	0.267
PaO2/FIO2	HA	55 ± 13	50 ± 8	49 ± 8	47 ± 8	43 ± 8	0.811
PaO2/FIO2	Control	59 ± 14	52 ± 7	51 ± 6	49 ± 7	42 ± 6	0.811
Pplat (cmH2O)	HA	18 ± 2	18 ± 2	18 ± 1	18 ± 1	19 ± 1	0.363
Pplat (cmH2O)	Control	19 ± 2	20 ± 2	20 ± 1	19 ± 1	21 ± 1	0.363
SaO2 (%)	HA	96 ± 1	95 ± 1	94 ± 1	94 ± 2	92 ± 2	0.813
SaO2 (%)	Control	96 ± 2	96 ± 1	96 ± 1	95 ± 1	93 ± 2	0.813

Cstat static compliance, EVLW extra vascular lung water, MPAP mean pulmonary arterial pressure, PaO2/FIO2 arterial oxygen partial pressure to fractional inspired oxygen ratio, Pplat plateau pressure, SaO2 arterial oxygen saturation. Values expressed as mean ± SD. No difference between groups throughout the experiment (mixed model analysis)