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Intensive Care Medicine Experimental
Fig. 7 | Intensive Care Medicine Experimental

Fig. 7

From: Comparison of whole blood cytokine immunoassays for rapid, functional immune phenotyping in critically ill patients with sepsis

Fig. 7

TNF production, over time, in response to LPS stimulation of whole blood from critically ill survivors versus non-survivors. A Log2-transformed TNF concentration as measured by ELISpot immunoassay, B log2-transformed TNF concentration as measured by ELLA immunoassay. Top panels illustrate cytokine production per microliter of blood, and corresponding bottom panels illustrate cytokine production per 103 monocytes. Day 1 denotes the day of study enrollment; dots represent mean values ± SEM. P values denote significant differences between stimulated TNF production in whole blood of survivors versus non-survivors, based on linear mixed-effects analysis. At day 1, n = 24 survivors, 8 non-survivors (7 critically ill and septic and 1 critically ill and non-septic)

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