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Intensive Care Medicine Experimental
Fig. 8 | Intensive Care Medicine Experimental

Fig. 8

From: Comparison of whole blood cytokine immunoassays for rapid, functional immune phenotyping in critically ill patients with sepsis

Fig. 8

IFNγ production, over time, in response to stimulation of whole blood from critically ill survivors versus non-survivors. Cytokine concentrations are represented as log2-transformed values. A IFNγ concentration as measured by ELISpot and B ELLA immunoassays in response to LPS stimulation. C IFNγ concentration as measured by ELISpot and D ELLA in response to anti-CD3/anti-CD28 stimulation. E IFNγ concentration as measured by ELISpot and F ELLA in response to PMA stimulation. Day 1 denotes the day of study enrollment; dots represent mean values ± SEM. P values denote significant differences between stimulated TNF production in whole blood of survivors versus non-survivors, based on linear mixed-effects analysis. At day 1, n = 24 survivors, 8 non-survivors (7 critically ill and septic and 1 critically ill and non-septic)

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