Ultra-low tidal volume ventilation during cardiopulmonary resuscitation shows no mitigating effect on pulmonary end-organ damage compared to standard ventilation: insights from a porcine model

Intensive Care Medicine Experimental

Table 3 Individual items of the DAD score—overall assessment of the lung

Parameter	Group	Mean (± SD)	p
Alveolar edema	IPPV	19.2 (± 2.4)	0.942
	ULTVV	17.5 (± 10.4)
	Sham	18.2 (± 8.6)
Interstitial edema	IPPV	55.6 (± 9.5)	0.897
	ULTVV	53.8 (± 6.2)
	Sham	53.0 (± 11.1)
Hemorrhage	IPPV	17.6 (± 5.1)	0.530
	ULTVV	17.7 (± 14.1)
	Sham	11.4 (± 7.0)
Inflammation	IPPV	46.8 (± 5.6)	0.269
	ULTVV	51.2 (± 3.4)
	Sham	55.0 (± 10.8)
Epithelial damage	IPPV	64.6 (± 7.0)	0.217
	ULTVV	59.2 (± 9.0)
	Sham	52.4 (± 14.2)
Microatelectasis	IPPV	30.2 (± 7.0)	0.503
	ULTVV	31.0 (± 5.8)
	Sham	35.6 (± 10.2)
Overdistension	IPPV	45.8 (± 9.5)	0.116
	ULTVV	44.5 (± 7.5)
	Sham	32.8 (± 13.1)

Group effects are analyzed by univariate ANOVA with post-hoc Bonferroni correction. There was no statistically significant difference between the groups in the individual items of the DAD score. n(IPPV) = 5; n(ULTVV) = 6; n(sham) = 5
DAD diffuse alveolar damage, IPPV intermittent positive pressure ventilation, ULTVV: ultra-low tidal volume ventilation