Fig. 1

Differences in clinical variables, monocyte and lymphocyte function between non-haematology and haematology patients. Comparison of patients admitted to the Intensive Care Unit with a non-haematology (Non-HO, n = 33), or haematology (HO, n = 11) diagnosis. Healthy volunteers (n = 17) are included as a reference. Innate immune response (a.) including neutrophil count (i.), monocyte count (ii.), and monocyte phagocytosis as measured by pHRodo (iii.), with example contour plot of non-HO (iv.) and HO (v.). Adaptive immune response (b.–c.) including lymphocyte count (b.i.) CD4 lymphocyte IL-7 receptor (IL-7R) expression (b.ii.) and correlation plot of IL-7R with percentage cell death of non-HO (b.iii.) and HO (b.iv.), apoptosis (c.i.), and programmed cell death receptor-1 (PD-1) expression (c.ii.) correlation plot of PD-1 with percentage cell death of non-HO (c.iii.) and HO (c.iv.) patients. LPS-induced cytokine release (d.) including IL-1β (i.), TNF-α (ii.) and IL-10 (iii.). Data compared using Mann Whitney test. Only p < 0.1 shown