Metabolic disturbances potentially attributable to clogging during continuous renal replacement therapy

Intensive Care Medicine Experimental

Table 2 Parameters of metabolic disturbances at start of CRRT runs

	Markers of clogging at the first measurement after start CRRT (T0)				Subgroup first-clogging (T0)				Subgroup first-CRRT run(T0)
	Overall	Non-clogging	Clogging	p value (Non-clogging vs. clogging)	Overall	Non-clogging	Clogging	p value (Non-clogging vs. clogging)	Overall	Non-clogging	Clogging	p value (Non-clogging vs. clogging)
Sodium (mmol/l)	141	140	145	< 0.001	140	140	146	< 0.001	146	145	146	0.236
Sodium (mmol/l)	[137–145]	[137–144]	[144–147]	< 0.001	[137–144]	[137–144]	[144–148]	< 0.001	[143–149]	[142–148]	[146–150]	0.236
Bicarbonate (mmol/l)	23	23	25	< 0.001	23	23	24	0.009	21	21	24	0.138
Bicarbonate (mmol/l)	[21–24]	[21–25]	[24–27]	< 0.001	[21–25]	[21–25]	[23–27]	0.009	[20–24]	[20–23]	[20–26]	0.138
CorrectedAlb Ca (mmol/l)	2.54	2.53	2.55	0.383	2.54	2.43	2.56	0.548	2.54	2.45	2.5	0.2
CorrectedAlb Ca (mmol/l)	[2.44–2.65]	[2.42–2.64]	[2.46–2.66]	0.383	[2.42–2.64]	[2.42–2.64]	[2.42–2.66]	0.548	[2.34–2.56]	[2.32–2.55]	[2.41–2.61]	0.2
CaSR (mmol/l)	1.7	1.7	1.7	0.792	1.7	1.7	1.7	0.406	1.7	1.7	1.7	0.602
CaSR (mmol/l)	[1.7–1.7]	[1.7–1.7]	[1.7–1.7]	0.792	[1.7–1.7]	[1.7–1.7]	[1.7–1.7]	0.406	[1.7–1.7]	[1.7–1.7]	[1.7–1.7]	0.602

Table 2 illustrates median levels of markers employed for clogging detection at the baseline, which corresponds to the first measurement taken after initiating the CRRT run, for the entire study population. In addition, two distinct subgroup analyses were performed
In the first subgroup analysis, CRRT runs, where clogging first became evident for each individual patient were compared to all runs without clogging (referred to as the "first-clogging subgroup")
The second subgroup consisted of the initial CRRT run for each patient, known as the "first-CRRT subgroup." Notably, differences in marker levels observed at the onset of filter usage within the overall study population were not evident in the first-CRRT subgroup