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Intensive Care Medicine Experimental
Fig. 2 | Intensive Care Medicine Experimental

Fig. 2

From: Understanding the pathophysiology of acute critical illness: translational lessons from zebrafish models

Fig. 2

Sepsis models. A–D Sepsis and organ failure induced by lipopolysaccharide (LPS). The inflammatory caspase pathway in fibroblast cells and in the developing gut was revealed (A). Transgenic zebrafish lines displayed vascular leakage and changes in the expression of cellular junction proteins (B). In vivo, the slit2-robo4 pathway regulated vascular permeability (C). The extravascular migration of neutrophils and macrophages was visualized using a transgenic zebrafish model (D)

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