Fig. 3

Trauma and regeneration models. A–C Regeneration after injury. The il1b expression in epithelial cells regulated the apoptosis of regenerative cells (A). In angiogenesis after vessel injury, intraluminal pressure (IP) sensors in epithelial cells regulate elongation (B). In the injured heart, the expression of kl1a was essential for cardiomyogenesis (C). D–F Damage to the central nervous system. Wnt signaling in radial glial cells regulated brain regeneration (D). In adult zebrafish brains, glutamate and its receptor were important for the propagation of spreading depolarization (E). In spinal cord injury (SCI), the upregulation of ctgfa in bridging glia was identified. Localized epithelial-to-mesenchymal transition (EMT) was further revealed to be the key factor in spinal cord regeneration. Tnf is a direct signaling axis from activated macrophages to spinal progenitor cells and promotes regenerative neurogenesis (F)