Table 1 Summary of studies and findings discussed in the text

1

Sepsis

Pathogen-associated molecular patterns (PAMPs)

LPS-induced zebrafish endotoxemia

# Extravascular migration of neutrophils and macrophages

# Change of expression in the tight junction protein Cldn5a/b, scaffold junction protein ZO-1 and a late mediator of inflammation HMGB1

[10]

2

Noncanonical inflammasome process, inflammatory caspase

Knocking out caspy2 in zebrafish fibroblast cell

Knockdown of caspy2

# Pyroptosis and caspy2 oligomerization binding directly to LPS

# Noncanonical pathway determining mortality

[14]

4

Trauma

Pro-inflammatory cytokine in the healing process

cloche mutant

# Expression of ilb2 in response to tissue amputation and in migrating cells

# Function for ilb2 and irf8 in regulating regenerative cells apoptosis

[22]

5

Angiogenesis in wound healing

Transgenic expressing EGFR in endothelial cells

# Function of intraluminal pressure (IP) in angiogenesis

# Role of IP sensor, TOCA family of F-BAR proteins

[23]

6

Cardiomyogenesis in injured heart

Myocardium-specific klf1 knockdown model

# Role of Klf1 in proliferation of cardiomyocytes

[25]

7

Neurogenesis in injured brain

Stab injury model of optic tectum

# Radial glia (RG) cell regulating Wnt signaling

[27]

8

Spreading depolarization (SD) in brain

Recording SD model in tectum

# Role of NMDA receptors in SD

[28]

9

Neurogenesis in spinal cord injury

Disrupting/overexpressing connective tissue growth factor a (ctgfa)

Knockouts of epithelial-to-mesenchymal transition (EMT)-driving genes

Transgenic model with modified hdac1 expression in progenitor cells

# ctgfa accelerating glial bridging and functional regeneration

# Promotion of spinal cord repair through localized EMT

# Promotion of regenerative neurogenesis through hdac1 in spinal progenitors

[29,30,31]