Fig. 9

Impact of ECPELLA on global DO₂ with and without VV-ECMO Support. Upper panels represent the changes of global DO₂ without (SaO₂: 40%, A) and with (SaO₂: 80%, B) VV-ECMO, and the comparison between the two conditions (C) in BVF supported by ECPELLA. Haemoglobin concentration was set at 10 g/dL. Lower panels represent the changes of global DO₂ without (SaO₂: 40%, D) and with (SaO₂: 80%, E) VV-ECMO, and the comparison between the two conditions (F) in BVF with PH supported by ECPELLA. Different conditions are represented by different colours (light grey line: Impella alone, dark grey line: VA-ECMO with Impella, red line: with VV-ECMO) and markers (round: Impella, triangle: VA-ECMO with Impella). The changes in global DO₂ closely correspond to the changes in systemic flow in the ECPELLA support condition. The elevation of SaO₂, by using VV-ECMO, increased global DO₂ and augmented the effect of Impella support level on global DO₂ elevation. DO₂ oxygen delivery, VV-ECMO veno-venous membrane oxygenation, VA-ECMO veno-arterial extracorporeal membrane oxygenation, SaO₂ arterial oxygen saturation