Table 1 Characteristics of included studies (n = 20)
References | Sample size, n | Country | Study design | Clinical setting | Intervention/exposure* | Primary outcome(s) | Secondary outcome(s) |
|---|---|---|---|---|---|---|---|
Macdonald et al. [33] | 95 | Australia | Randomized controlled trial | Emergency/ICU; septic shock | Standard versus restricted IV fluid regime | Syn-1, Syn-4, HS, hyaluronan | Endothelial activation markers |
Ilyina et al. [34] | 18 | Russia | Prospective before and after study | Emergency/ICU; septic shock | IV crystalloid bolus (7 mL/kg) | Syn-1, HS | Hemodynamic status, fluid response, LOS, mortality (28-day), severity of pulmonary edema |
86 | Australia, United States | Prospective observational study | Emergency/ICU; septic shock | 24-h IV fluid administration | Syn-1, Syn-4, hyaluronan | Endothelial activation markers, ANP, ICU admission, LOS, mortality (30-day) | |
Bihari et al. [44] | 161 | Australia | Randomized controlled trial | Major surgery; abdominal | Liberal versus restrictive IV crystalloid regime | Syn (subtype unspecified) | Post-operative complications, LOS, disability, mortality (90-day, 1-year) |
Liu et al. [43] | 54 | China | Randomized controlled trial | Elective surgery; colorectal | Liberal versus restrictive IV fluid regime | Syn-1, HS, hyaluronan | ANP, LOS, post-operative recovery |
Saoraya et al. [31] | 96 | Thailand | Randomized controlled trial | Emergency; sepsis | Standard versus limited rate IV fluid regime | Syn-1 | Hemodynamic status, recovery, LOS, mortality (28-day, 90-day) |
Tapking et al. [46] | 39 | Germany | Prospective observational study | Inpatient; burns | 24-h IV fluid administration | Syn (subtype unspecified), HS | Mortality |
Wang et al. [40] | 80 | China | Randomized controlled trial | Elective surgery; retroperitoneal tumor resection | Liberal versus restrictive IV crystalloid regime | Syn-1 | Hemodynamic status, post-operative recovery/complications, mortality (1-year) |
Nemme et al. [41] | 26 | Latvia | Prospective before and after study | Elective surgery; hysterectomy | IV crystalloid bolus (25 mL/kg) | Syn-1, HS | BNP |
Hippensteel et al. [30] | 201 | United States | Prospective observational study | Emergency; septic shock | 24-h IV fluid administration | Syn-1, HS | Endothelial activation markers, ANP |
Smart et al. [35] | 65 | Australia | Randomized controlled trial | Emergency; sepsis | IV bolus 0.9 saline (10 mL/kg) versus 3% saline (5 mL/kg) | Syn-1, hyaluronan | Endothelial activation and inflammatory markers, hemodynamic status, 24-h fluid volumes, SOFA score, LOS |
Inkinen et al. [29] | 619 | Finland | Prospective observational study | ICU; sepsis and post-operative patients | 24-h IV fluid administration | Syn-1 | Acute kidney injury, mortality (90-day) |
Li et al. 2019 | 40 | China | Two group prospective before and after study | Elective surgery; glioma resection; hepatectomy | IV colloid bolus (15 mL/kg) | Syn-1, HS | Hemodynamic status, cerebral metabolism markers |
Pouska et al. [36] | 66 | Czech Republic | Randomized controlled trial | Emergency/ICU—septic shock patients; major spinal surgery | Fast versus slow rate IV crystalloid regime | Perfused boundary region | Hemodynamic status, fluid response |
Belavić et al. [39] | 90 | Croatia | Randomized controlled trial | Elective surgery; laparoscopic cholecystectomy | Liberal versus restrictive IV crystalloid regime | Syn-1, hyaluronan | Kidney function, liver function, inflammatory markers |
Smart et al. [28] | 138 | Australia | Prospective observational study | Emergency/ICU; sepsis | 24-h IV fluid administration | Syn-1, Syn-4, hyaluronan | ICU admission, LOS, mortality (30-day) |
Wu et al. [27] | 26 | China | Prospective observational study | Emergency/ICU—sepsis patients | 24-h fluid balance | Syn-1 | LOS, mortality (in-hospital) |
Chappell et al. [38] | 18 | Germany | Unspecified | Elective surgery; general surgery | IV colloid bolus (20 mL/kg) | Syn-1, HS, hyaluronan | ANP |
Powell et al. [37] | 30 | United States | Prospective before and after study | Elective surgery; cesarean section | IV crystalloid bolus (750 mL) | Syn-1, HS | ANP, hemodynamic status |
Berg et al. [45] | 12 | Sweden | Prospective before and after study | Healthy volunteers | IV crystalloid bolus (1000 mL) | Hyaluronan | Hemodynamic status |