From: Sepsis and obesity: a scoping review of diet-induced obesity murine models
Author | Blood glucose (mmol/L; IQR)i | Mortality (n = %)a | Biomarkers of organ dysfunction (SD) | MPO (U/100 mg tissue; SD) | IL-6 | TNFα |
---|---|---|---|---|---|---|
DeMartini [24] | NR | NR | ND cTNI 6 h (plasma) | ↑ (heart)a,b | NR | NR |
Frydrych [25] | NR | ↑ LFD-S: 20% HFD-S: 60% | NR | NR | ↑ 6 h (blood)a | ↓ 18 h (blood)a |
Gomes [26] | NDh LFD: 20.18 (15.35–23.15) HFD:29.08 (22.77–32.74) LFD-S: 17.03 (14.95–18.03) HFD-S:21.24 (14.24–25.64) | ↑ LFD-S: 23.8% HFD-S: 41.7% | ND ALT (serum; U/L): LFD: 22.01 (22.01–88.05 IQR) HFD: 200.3 (123.3–277.4 IQR) LFD-S: 202.5 (168.4–231.1 IQR) HFD-S: 224.5 (154.1–306 IQR) ↑ Liver histology scoreb | NR | ↑ (serum)a ↑ (liver)b | ↑ (serum)a,b ↑ (liver)b |
Goossens [27] | NR | ND LFD-S: 17% HFD-S: 17% | ↑ atrophy(muscle)b | NR | NR | NR |
Kaplan [28] | NR | ↑ | ↑ lung injury scorea HFD: 3.5 ± 0.5 AU HFD-S: 8.6 ± 0.9 AU | ↑ 3hb, 6 hab, 18 ha,b (liver) ↑ 1 ha,b, 3 hb, 6 ha,b, 18 ha (lung) | ↓ 3 ha,b (plasma) ↑ 1 hb, 3 hb, 6 hb, 18 hb (plasma) | ↓ 3 ha (plasma) ↑ 6 hb 18 hb (plasma) |
Kaplan [29] | ↑e | ↑ | ↑ ALT (U/L; plasma)a,b LFD: 88 ± 21 HFD: 63 ± 4 LFD-S: 154 ± 10 HFD-S: 227 ± 32 | ↑6 h (liver)a,b LFD-S: 7 ± 0.3 HFD-S: 11.4 ± 1.4 | ↑ (plasma; U/L)a,b LFD: 88 ± 21 HFD: 63 ± 4 LFD-S: 154 ± 10 HFD-S: 227 ± 32 | ↓ (plasma)a ↑ (plasma)b |
Khan [30] | ↑e,f | NR | ↑ liver histology scorea,b | ND 6 weeks of diet (lung; U/mg tissue) LFD: 51.2 ± 3.38 HFD-S: 46.9 ± 2.20 ↓ 15 weeks of diet (lung; U/mg tissue)a,d LFD: 44.1 ± 2.86 LFD-DR: 63.2 ± 5.60 HFD-S: 26.3 ± 3.80 ↓ 27 weeks of diet (lung; U/mg tissue)a,d LFD: 47.5 ± 2.70 LFD-DR: 43.9 ± 3.29 HFD-S: 28.3 ± 5.08 | ↑ 6 h (liver)b ND 6 h (liver)a | ND 6 h (liver) |
Lewis [31] | ↑e 6hb, 24hb | ↓ LFD-S: 75% HFD-S: 33% | ↑creatinine 24 ha,b (plasma) ↑ NGAL 24 ha,b (kidney) ↑ ketones 6 hb, 12 hb, 36 hb, 48hb (blood) | NR | ↓ 6 h (plasma)a ND 24 h (plasma)a ↑ 24 h (plasma)b | ND 24 ha (plasma) ↑ 24 hb (plasma) |
Panpetch [32] | ↑e | ND | ↑ ALT (serum) 24 hb,c ↑ creatinine 24 ha,b,c (serum) | NR | ↑ (serum) 24 ha,b,c | ↑ (serum)a,b,c |
Rivera [33] | NR | NR | NR | NR | NR | ↑ (liver) 6 ha,b |
Siegl [34] | NR | ↑ | ↓interstitial and alveolar edema 24 ha, 48 ha ND: liver histology | NR | ↑ (serum; ng/ml) 6 hb: LFD-S: 20.8 ± 2.2 HFD-S: 18.2 ± 2.6 | ↓ (serum; ng/ml)a 24 h: LFD-S: 4.2 ± 1.0 HFD-S: 1.3 ± 0.1 48 h: LFD-S: 5.7 ± 0.9 HFD-S: 3.0 ± 0.7 |
Souza [35] | NR | ↑ | NR | NR | ↑ hypothalamusa,b | ↑ hypothalamusa |
Strandberg [36] | NR | ↑ | NR | NR | ND 5–7 days (serum, liver, spleen) | ↑ ND 5–7 days (liver, spleen, serum) |
Su [37] | NR | NR | ↑BUN (mg/dL; plasma)c: LFD:18.9 ± 0.90 12 h: HFD-S: 67.4 ± 8.40 24 h: HFD-S: 97.1 ± 6.10 48: HFD-S: 139.9 ± 14.40 ↑ Creatinine (mg/dL; plasma)c: LFD: 0.09 ± 0.01 12 h: HFD-S: 0.14 ± 0.03 24 h: HFD-S: 0.70 ± 0.09 48 h: HFD-S: 1.10 ± 0.28 ↑ NGAL (ug/dL; plasma)c: LFD: 0.08 ± 0.01 12 h: HFD-S: 3.52 ± 1.84 24 h: HFD-S: 52.3 ± 5.40 48 h: HFD-S: 39.5 ± 32.70 | ↑ 12 hc, 14 hc, 48 hc (kidney) | ↑12 hc, 24c, 48 hc ( kidney) | ↑12 hc, 24c, 48 hc (kidney) |
Vankrunkelsven [38] | ↑ glucosee ~ 85 hc, ~ 125 hc | ND | ↑ketones (blood)c ↓ liver edema 125 hc ↓ BUN (plasma)c | NR | ↑ (plasma)b | ↑ (plasma)b |
Williamson [39] | NR | NR | ND ALT 18 h (plasma; U/L) LFD-S:118 ± 33 HFD-S:102 ± 45 | ↑ 18 h (lung)a,b HFD: 53 ± 22 HFD-S: 124 ± 31 LFD-S: 84 ± 29 ND 18 h (liver) | NR | NR |
Yeh [40] | NR | NR | NR | ↑ 12 h, 24 h (lung)b | NR | NR |