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Intensive Care Medicine Experimental
Fig. 4 | Intensive Care Medicine Experimental

Fig. 4

From: BET-inhibitor DYB-41 reduces pulmonary inflammation and local and systemic cytokine levels in LPS-induced acute respiratory distress syndrome: an experimental rodent study

Fig. 4

a–f Representative histopathologic images; HE stain, 100× (A, C, E) and 400× (B, D, F) magnification. A, B Reference animal, no LPS, placebo (ventilation only): mild perivascular edema (arrow). C, D Control animal; the widened perivascular space is occupied by numerous neutrophils (arrow) and macrophages, which are also present in surrounding alveoli. E, F Animal with DYB-41: infiltration of neutrophils and early cellular necrosis (acute, arrow), alveolar macrophages (arrowhead) and moderate alveolar edema (asterisk)

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