Fig. 1
From: Lung- and diaphragm-protective strategies in acute respiratory failure: an in silico trial
Research approach. The in silico trial was implemented by applying the physiology-based mathematical model to predict the effect of titrating ventilatory support (in PSV and PAV+ modes) and sedation according to a predefined algorithm on LDP targets in a simulated population of patients with acute hypoxemic respiratory failure. To assess the face validity of the in silico trial results, the predicted probability of achieving LDP targets (computed by a statistical model derived from the in silico trial) was compared to the observed outcome in a real-world clinical trial of the titration procedure