Table 1 Characteristics of the in silico trial population
From: Lung- and diaphragm-protective strategies in acute respiratory failure: an in silico trial
Mode of ventilation | ||
|---|---|---|
Patient characteristics [mean (SD)] | PSV or PAV+ | |
Simulated baseline characteristics supplied to the model | Age [years] | 55 (10) |
Weight [kg] | 85 (15) | |
Height [m] | 1.70 (0.08) | |
Body mass index [kg/m2] | 29.6 (5.9) | |
Sex (female) [%] | 49 | |
PaO2 [mmHg] | 100 (19) | |
VCO2 [mL/min] | 223 (37) | |
Anatomical dead space [mL] | 128 (29) | |
Alveolar dead space fraction [%] | 37 (14) | |
Respiratory system resistance [cmH2O/(L/s)] | 11 (2.4) | |
Intrinsic PEEP [cmH2O] | 1.5 (0.8) | |
Lung compliance [mL/cmH2O] | 47 (13) | |
Chest wall compliance [mL/cmH2O] | 125 (180) | |
Strong ion difference [mEq] | 34 (7) | |
Respiratory rate [/min] | 28 (5) |
PSV | PAV+ | ||
|---|---|---|---|
Simulated baseline patient characteristics computed after applying the model on baseline ventilator and sedation settings | PaCO2 [mmHg] | 35 (9) | 36 (9) |
Plasma bicarbonate [mmol/L] | 24 (7) | 24 (7) | |
pH | 7.44 (0.04) | 7.43 (0.02) | |
Tidal volume (Vt) [mL] | 568 (171) | 566 (192) | |
Tidal volume/kg PBW [mL/kg] | 9 (2.9) | 9 (3.2) | |
Minute ventilation [L/min] | 15.6 (4.7) | 15.5 (5.1) | |
Ventilatory ratio | 2.3 (0.9) | 2.3 (0.9) | |
ΔPes [cmH2O] | 9 (8) | 9 (4) | |
ΔPL,dyn [cmH2O] | 18 (7) | 18 (7) |