Table 3 Anatomical and physiological study variables collected at 48h, according to RIFLE classification
Variable | NO AKI (n: 25) | RIFLE 1: risk (n: 15) | RIFLE 2: injury (n: 14) | RIFLE 3: failure (n: 10) | p-value |
|---|---|---|---|---|---|
Respiratory variables | |||||
Tidal volume (mL) | 413 (± 219) | 398 (± 175) | 434 (± 218) | 372 (± 134) | 0.893 |
Respiratory rate (bpm) | 29 (± 12) | 26 (± 11) | 26 (± 9) | 21 (± 9) | 0.084 |
Mean airway pressure (cmH2O) | 15.8 (± 6.2) | 15.9 (± 5.7) | 20.4 (± 8.3) | 26.2 (± 8.3) | 0.001 |
PEEP measured (cmH2O) | 9.2 (± 6.0) | 10.1 (± 6.4) | 12.9 (± 7.4) | 18.5 (± 8.7) | 0.001 |
Driving pressure (cmH2O) | 7.2 (± 3.6) | 7.8 (± 2.8) | 7.9 (± 2.6) | 5.6 (± 2.6) | 0.120 |
Mean pleural pressure (cmH2O) | 5.2 (± 2.7) | 5.2 (± 2.5) | 6.0 (± 4.2) | 10.5 (± 3.8) | < 0.001 |
Stress-Transpulmonary pressure (mmHg) | 11.8 (± 5.2) | 12.4 (± 4.8) | 14.7 (± 8.8) | 11.5 (± 3.8) | 0.472 |
Strain, fraction | 1.45 (± 0.89) | 1.15 (± 0.55) | 1.70 (± 1.17) | 1.26 (± 0.50) | 0.348 |
Airway resistance (cmH2O*min/L) | 0.20 (± 0.09) | 0.22 (± 0.08) | 0.21 (± 0.05) | 0.23 (± 0.09) | 0.740 |
Elastance, respiratory system (cmH2O/mL) | 48.9 (± 18.0) | 52.1 (± 19.6) | 49.6 (± 12.6) | 56.1 (± 14.8) | 0.693 |
Elastance, lung (cmH2O/mL) | 31.8 (± 16.3) | 36.9 (± 19.4) | 34.2 (± 7.9) | 34.1 (± 13.4) | 0.872 |
Elastance, chest-wall (cmH2O/mL) | 15.8 (± 6.0) | 16.2 (± 5.8) | 15.3 (± 7.1) | 22.0 (± 8.4) | 0.069 |
Specific elastance | 9.23 (± 4.57) | 12.69 (± 6.97) | 9.69 (± 3.03) | 9.94 (± 4.21) | 0.192 |
Mechanical power, respiratory system (J/min) | 24.7 (± 13.0) | 23.7 (± 7.9) | 29.9 (± 12.5) | 25.4 (± 8.8) | 0.461 |
Mechanical power, lung (J/min) | 18.9 (± 10.8) | 18.3 (± 7.5) | 23.3 (± 9.7) | 17.6 (± 7.2) | 0.401 |
Hemodynamic | |||||
Heart rate (bpm) | 86 (± 21) | 87 (± 21) | 109 (± 23) | 115 (± 20) | < 0.001 |
Mean arterial pressure (mmHg) | 72 (± 12) | 71 (± 19) | 71 (± 14) | 61 (± 9) | 0.186 |
Central venous pressure (mmHg) | 10.7 (± 3.8) | 10.3 (± 4.7) | 14.2 (± 5.6) | 15.1 (± 4.9) | 0.013 |
Mean perfusion pressure (mmHg) | 61 (± 12) | 61 (± 19) | 57 (± 15) | 46 (± 10) | 0.036 |
Mean pulmonary artery pressure (mmHg) | 25 (± 7) | 24 (± 8) | 32 (± 8) | 34 (± 6) | 0.001 |
Cardiac output (L/min) | 2.86 (± 0.77) | 2.60 (± 0.65) | 4.11 (± 1.74) | 4.57 (± 1.86) | < 0.001 |
Central venous oxygen saturation (%) | 77 (± 9) | 76 (± 8) | 73 (± 16) | 81 (± 5) | 0.394 |
Lactates (mg/dL) | 0.63 (± 0.29) | 0.62 (± 0.259) | 1.42 (± 1.62) | 1.39 (± 0.79) | 0.011 |
Infused catecholamines (mcg/Kg) | 4.3 (± 6.0) | 4.4 (± 5.7) | 12.9 (± 15.3) | 11.0 (± 17.0) | 0.034 |
Blood gas analysis | |||||
PaO2 (mmHg) | 222 (± 28) | 229 (± 189) | 213 (± 46) | 227 (± 27) | 0.548 |
PaCO2 (mmHg) | 21 (± 10) | 18 (± 4) | 24 (± 20) | 30 (± 20) | 0.259 |
pH | 7.57 (± 0.06) | 7.59 (± 0.05) | 7.52 (± 0.14) | 7.45 (± 0.16) | 0.005 |