T0 | T1 | T2 | T3 | p-value | |
---|---|---|---|---|---|
Isoflurane insp (%) | 0 [0. 0]*T1. T2 | 0.33 [0.19, 0.39] *T0. T3 | 0.35 [0.21, 0.55]*T0. T3 | 0 [0. 0]*T1. T2 | < 0.001* |
Isoflurane exp (%) | 0 [0. 0]*T1. T2 | 0.65 [0.46, 0.81]*T0, T3 | 0.78 [0.55, 1.00]*T0. T3 | 0 [0. 0]*T1. T2 | < 0.001* |
LiMAx (µg kg−1 h−1) | 177 [129, 298]*T1. T2 | 67 [15, 122]*T0. T3 | 49 [8, 165]*T0.T3 | 247 [152, 403]*T1. T2 | < 0.001* |
Bilirubin (mg/dl) | 0.71 [0.28, 0.86] | 0.46 [0.27, 0.79] | 0.56 [0.30, 1.13] | 0.67 [0.20, 1.22] | 0.529 |
Creatinine (mg/dl) | 0.77 [0.59, 1.26] | 0.86 [0.54, 1.25] | 0.79 [0.67, 0.97] | 0.85 [0.63, 1.24] | 0.345 |
INR | 1.15 [1.04, 1.31] | 1.14 [1.05, 1.30] | 1.10 [1.03, 1.17] | 1.09 [1.03, 1.14] | 0.155 |
MELD score | 9.7 [7.1, 22.8] | 9.7 [7.2, 22.9] | 8.4 [7.5, 21.9] | 9.1 [7.3, 11.5] | 0.067 |
AST (U/l) | 36.5 [23.3, 90.3] | 36.0 [26.5, 92.0] | 33.0 [25.0, 58.0] | 65.0 [44.3,103.5] | 0.344 |
ALT (U/l) | 29.0 [14.0, 78.0] | 23.0 [13.5, 53.5] | 19.0 [13.0, 30.0] | 37.5 [25.3, 74.3] | 0.288 |
AST/ALT ratio | 1.14 [1.00, 1.89] | 1.57 [0.92, 2.21] | 1.56 [0.94, 2.21] | 1.53 [1.05, 2.21] | 0.313 |
Lactate (mmol/l) | 1.13 [0.75, 1.31] | 1.30 [0.86, 1.90] | 1.39 [0.97, 1.78] | 1.02 [0.87, 1.33] | 0.123 |
Leucocytes (g/l) | 9.9 [6.1, 18.3] | 9.9 [8.5, 17.8] | 12.5 [9.0, 14.3] | 13.0 [9.0, 25.6] | 0.519 |
Hemoglobin (g/l) | 94 [90, 106] | 89 [82, 102] | 94 [82, 102] | 87 [73, 95] | 0.135 |
Hematocrit (%) | 0.30 [0.27, 0.33] | 0.28 [0.25, 0.31] | 0.29 [0.27, 0.31] | 0.27 [0.23, 0.30] | 0.065 |
Thrombocytes (g/l) | 216 [132, 271] | 216 [97, 270] | 225 [186, 303] | 250 [217, 403] | 0.084 |
MAP (mmHG) | 77 [65, 85] | 74 [71, 83] | 77 [69, 91] | 85 [69, 98] | 0.425 |
Horowitz index | 244 [173, 359] | 283 [184, 336] | 253 [189, 315] | 240 [175, 333] | 0.718 |
Noradrenalin (µg kg−1 min−1) | 0.096 [0.025, 0.130] | 0.107 [0.055, 0.255]*T3 | 0.100 [0.037, 0.194]*T3 | 0.000 [0.000, 0.047] *T1, *T2 | 0.022* |
SOFA score | 10.0 [8.8, 12.0]*T3 | 10.5 [9.0, 12.3]*T3 | 10.0 [9.0, 11.0]*T3 | 8.0 [6.3, 10.0]*T0, T1, T2 | 0.001* |